RT Journal Article
T1 Regular monitoring of cytomegalovirus-specific cell-mediated immunity in intermediate-risk kidney transplant recipients: predictive value of the immediate post-transplant assessment.
A1 Fernandez-Ruiz, M
A1 Gimenez, E
A1 Vinuesa, V
A1 Ruiz-Merlo, T
A1 Parra, P
A1 Amat, P
A1 Montejo, M
A1 Paez-Vega, A
A1 Cantisan, S
A1 Torre-Cisneros, J
A1 Fortun, J
A1 Andres, A
A1 San Juan, R
A1 Lopez-Medrano, F
A1 Navarro, D
A1 Aguado, J M
K1 Cell-mediated immunity
K1 Cytomegalovirus
K1 Immune monitoring intracellular cytokine staining
K1 Kidney transplantation
AB Previous studies on monitoring of post-transplant cytomegalovirus (CMV)-specific cell-mediated immunity (CMI) are limited by single-centre designs and disparate risk categories. We aimed to assess the clinical value of a regular monitoring strategy in a large multicentre cohort of intermediate-risk kidney transplant (KT) recipients. We recruited 124 CMV-seropositive KT recipients with no T-cell-depleting induction pre-emptively managed at four Spanish institutions. CMV-specific interferon-γ-producing CD4+ and CD8+ T cells were counted through the first post-transplant year by intracellular cytokine staining after stimulation with pp65 and immediate early-1 peptides (mean of six measurements per patient). The primary outcome was the occurrence of any CMV event (asymptomatic infection and/or disease). Optimal cut-off values for CMV-specific T cells were calculated at baseline and day 15. Twelve-month cumulative incidence of CMV infection and/or disease was 47.6%. Patients with pre-transplant CMV-specific CD8+ T-cell count  Monitoring for CMV-specific CMI in intermediate-risk KT recipients must be regular to reflect dynamic changes in overall immunosuppression and individual susceptibility. The early assessment at post-transplant day 15 remains particularly informative.
PB Elsevier
YR 2018
FD 2018-05-17
LK http://hdl.handle.net/10668/12511
UL http://hdl.handle.net/10668/12511
LA en
NO Fernández-Ruiz M, Giménez E, Vinuesa V, Ruiz-Merlo T, Parra P, Amat P, et al. Regular monitoring of cytomegalovirus-specific cell-mediated immunity in intermediate-risk kidney transplant recipients: predictive value of the immediate post-transplant assessment. Clin Microbiol Infect. 2019 Mar;25(3):381.e1-381.e10
DS RISalud
RD Apr 12, 2025