RT Journal Article
T1 Principles of precision medicine in stroke.
A1 Hinman, Jason D
A1 Rost, Natalia S
A1 Leung, Thomas W
A1 Montaner, Joan
A1 Muir, Keith W
A1 Brown, Scott
A1 Arenillas, Juan F
A1 Feldmann, Edward
A1 Liebeskind, David S
K1 CEREBRAL BLOOD FLOW
K1 CEREBROVASCULAR
K1 IMAGE ANALYSIS
K1 NEUROGENETICS
K1 STATISTICS
AB The era of precision medicine has arrived and conveys tremendous potential, particularly for stroke neurology. The diagnosis of stroke, its underlying aetiology, theranostic strategies, recurrence risk and path to recovery are populated by a series of highly individualised questions. Moreover, the phenotypic complexity of a clinical diagnosis of stroke makes a simple genetic risk assessment only partially informative on an individual basis. The guiding principles of precision medicine in stroke underscore the need to identify, value, organise and analyse the multitude of variables obtained from each individual to generate a precise approach to optimise cerebrovascular health. Existing data may be leveraged with novel technologies, informatics and practical clinical paradigms to apply these principles in stroke and realise the promise of precision medicine. Importantly, precision medicine in stroke will only be realised once efforts to collect, value and synthesise the wealth of data collected in clinical trials and routine care starts. Stroke theranostics, the ultimate vision of synchronising tailored therapeutic strategies based on specific diagnostic data, demand cerebrovascular expertise on big data approaches to clinically relevant paradigms. This review considers such challenges and delineates the principles on a roadmap for rational application of precision medicine to stroke and cerebrovascular health.
YR 2016
FD 2016-10-19
LK http://hdl.handle.net/10668/10660
UL http://hdl.handle.net/10668/10660
LA en
DS RISalud
RD Apr 11, 2025