RT Journal Article
T1 What We Know and What We Need to Know about Aromatic and Cationic Biogenic Amines in the Gastrointestinal Tract.
A1 Fernández-Reina, Alberto
A1 Urdiales, José Luis
A1 Sánchez-Jiménez, Francisca
K1 bowel diseases
K1 catecholamines
K1 colon cancer
K1 gastric cancer
K1 gastrointestinal tract
K1 histamine
K1 inflammation
K1 nutrition
K1 polyamines
K1 serotonin
AB Biogenic amines derived from basic and aromatic amino acids (B/A-BAs), polyamines, histamine, serotonin, and catecholamines are a group of molecules playing essential roles in many relevant physiological processes, including cell proliferation, immune response, nutrition and reproduction. All these physiological effects involve a variety of tissue-specific cellular receptors and signalling pathways, which conforms to a very complex network that is not yet well-characterized. Strong evidence has proved the importance of this group of molecules in the gastrointestinal context, also playing roles in several pathologies. This work is based on the hypothesis that integration of biomedical information helps to reach new translational actions. Thus, the major aim of this work is to combine scientific knowledge on biomolecules, metabolism and physiology of the main B/A-BAs involved in the pathophysiology of the gastrointestinal tract, in order to point out important gaps in information and other facts deserving further research efforts in order to connect molecular information with pathophysiological observations.
SN 2304-8158
YR 2018
FD 2018-09-04
LK https://hdl.handle.net/10668/25100
UL https://hdl.handle.net/10668/25100
LA en
DS RISalud
RD Apr 6, 2025