RT Journal Article
T1 Immune signatures and disorder-specific patterns in a cross-disorder gene expression analysis.
A1 de Jong, Simone
A1 Newhouse, Stephen J
A1 Patel, Hamel
A1 Lee, Sanghyuck
A1 Dempster, David
A1 Curtis, Charles
A1 Paya-Cano, Jose
A1 Murphy, Declan
A1 Wilson, C Ellie
A1 Horder, Jamie
A1 Mendez, M Andreina
A1 Asherson, Philip
A1 Rivera, Margarita
A1 Costello, Helen
A1 Maltezos, Stefanos
A1 Whitwell, Susannah
A1 Pitts, Mark
A1 Tye, Charlotte
A1 Ashwood, Karen L
A1 Bolton, Patrick
A1 Curran, Sarah
A1 McGuffin, Peter
A1 Dobson, Richard
A1 Breen, Gerome
K1 Atención
K1 Trastorno por déficit de atención con hiperactividad
K1 Trastorno del espectro autista
K1 Trastorno depresivo mayor
K1 Diagnóstico dual (Psiquiatría)
K1 Redes reguladoras de genes
K1 Genómica
K1 Humanos
K1 Factores de riesgo
K1 Transcriptoma
AB BACKGROUNDRecent studies point to overlap between neuropsychiatric disorders in symptomatology and genetic aetiology.AIMSTo systematically investigate genomics overlap between childhood and adult attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and major depressive disorder (MDD).METHODAnalysis of whole-genome blood gene expression and genetic risk scores of 318 individuals. Participants included individuals affected with adult ADHD (n = 93), childhood ADHD (n = 17), MDD (n = 63), ASD (n = 51), childhood dual diagnosis of ADHD-ASD (n = 16) and healthy controls (n = 78).RESULTSWeighted gene co-expression analysis results reveal disorder-specific signatures for childhood ADHD and MDD, and also highlight two immune-related gene co-expression modules correlating inversely with MDD and adult ADHD disease status. We find no significant relationship between polygenic risk scores and gene expression signatures.CONCLUSIONSOur results reveal disorder overlap and specificity at the genetic and gene expression level. They suggest new pathways contributing to distinct pathophysiology in psychiatric disorders and shed light on potential shared genomic risk factors.
PB Royal College of Psychiatrists
SN 0007-1250
YR 2016
FD 2016-05-05
LK http://hdl.handle.net/10668/2318
UL http://hdl.handle.net/10668/2318
LA en
NO de Jong S, Newhouse SJ,  Patel H,  Lee S, Dempster D, Curtis C et al.  Immune signatures and disorder-specific patterns in a cross-disorder gene expression analysis. The British Journal of Psychiatry May 2016, bjp.bp.115.175471
NO JOURNAL ARTICLE;
DS RISalud
RD Apr 11, 2025