RT Journal Article
T1 Proinflammatory Polyphosphate Increases in Plasma of Obese Children with Insulin Resistance and Adults with Severe Type 2 Diabetes.
A1 Montilla, Marcela
A1 Liberato, Andrea
A1 Ruiz-Ocaña, Pablo
A1 Saez-Benito, Ana
A1 Aguilar-Diosdado, Manuel
A1 Lechuga-Sancho, Alfonso Maria
A1 Ruiz, Felix A
K1 Biomarker
K1 Children
K1 Inflammation
K1 Insulin resistance
K1 Obesity
K1 Polyphosphate
K1 Type 2 diabetes
AB Obesity increases the risk of insulin resistance and type 2 diabetes through increased inflammation at cellular and tissue levels. Therefore, study of the molecular elements involved in obesity-related inflammation may contribute to preventing and controlling it. Inorganic polyphosphate is a natural phosphate polymer that has recently been attracting more attention for its role in inflammation and hemostasis processes. Polyphosphates are one of the main constituents of human platelets, which are secreted after platelet activation. Among other roles, they interact with multiple proteins of the coagulation cascade, trigger bradykinin release, and inhibit the complement system. Despite its importance, determinations of polyphosphate levels in blood plasma had been elusive until recently, when we developed a method to detect these levels precisely. Here, we perform cross sectional studies to evaluate plasma polyphosphate in: 25 children, most of them with obesity and overweight, and 20 adults, half of them with severe type 2 diabetes. Our results show that polyphosphate increases, in a significant manner, in children with insulin resistance and in type 2 diabetes patients. As we demonstrated before that polyphosphate decreases in healthy overweight individuals, these results suggest that this polymer could be an inflammation biomarker in the metabolic disease onset before diabetes.
PB MDPI
YR 2022
FD 2022-10-28
LK http://hdl.handle.net/10668/21514
UL http://hdl.handle.net/10668/21514
LA en
NO Montilla M, Liberato A, Ruiz-Ocaña P, Sáez-Benito A, Aguilar-Diosdado M, Lechuga-Sancho AM, et al. Proinflammatory Polyphosphate Increases in Plasma of Obese Children with Insulin Resistance and Adults with Severe Type 2 Diabetes. Nutrients. 2022 Nov 1;14(21):4601
DS RISalud
RD Apr 20, 2025