RT Journal Article
T1 Subjects develop tolerance to Pru p 3 but respiratory allergy to Pru p 9: A large study group from a peach exposed population.
A1 Somoza, Maria Luisa
A1 Perez-Sanchez, Natalia
A1 Victorio-Puche, Laura
A1 Martin-Pedraza, Laura
A1 Esteban Rodriguez, Angel
A1 Blanca-Lopez, Natalia
A1 Abel-Fernandez Gonzalez, Eva
A1 Ruano-Zaragoza, Maria
A1 Prieto-Moreno-Pfeifer, Ana
A1 Fernandez-Caldas, Enrique
A1 Moran-Morales, Miriam
A1 Fernandez-Sanchez, Francisco Javier
A1 Lopez-Sanchez, Jose Damian
A1 Jimenez-Rodriguez, Teodorikez Wilfox
A1 Subiza-Garrido-Lestache, Jose Luis
A1 Canto-Diez, Gabriela
A1 Blanca-Gomez, Miguel
A1 Cornejo-Garcia, Jose Antonio
K1 Population Groups
K1 Prunus persica
K1 Young Adult
AB Peach tree allergens are present in fruit, pollen, branches, and leaves, and can induce systemic, respiratory, cutaneous, and gastrointestinal symptoms. We studied the capacity of peach fruit/Pru p 1, Pru p 3, Pru p 4, Pru p 7 and peach pollen/Pru p 9 for inducing symptoms following oral or respiratory exposure in a large group of subjects. We included 716 adults (aged 21 to 83 y.o.) exposed to peach tree pollen and fruit intake in the study population. Participants completed a questionnaire and were skin tested with a panel of inhalant and food allergens, including peach tree pollen, Pru p 9 and peach fruit skin extract. Immunoglobulin E antibodies (SIgE) to Pru p 1, Pru p 3, Pru p 4 and Pru p 7 were quantified. Sensitised subjects underwent oral food challenge with peach fruit and nasal provocation test with peach tree pollen and Pru p 9. The prevalence of sensitisation to peach fruit was 5% and most of these had SIgE to Pru p 3, with a very low proportion to Pru p 4 SIgE and no SIgE to Pru p 1 and Pru p 7. In only 1.8%, anaphylaxis was the clinical entity induced. Cases with positive skin tests to peach and SIgE to Pru p 3 presented a good tolerance after oral challenge with peach fruit. The prevalence of skin sensitisation to peach tree pollen was 22%, with almost half recognising Pru p 9. This induced respiratory symptoms in those evaluated by nasal provocation. In a large population group exposed to peach fruit and peach tree pollen, most individuals were tolerant, even in those with SIgE to Pru p 3. A positive response to Pru p 9 was associated with respiratory allergy.
PB Public Library of Science
YR 2021
FD 2021-08-19
LK http://hdl.handle.net/10668/18393
UL http://hdl.handle.net/10668/18393
LA en
NO Somoza ML, Pérez-Sánchez N, Victorio-Puche L, Martín-Pedraza L, Esteban Rodríguez A, Blanca-López N, et al. Subjects develop tolerance to Pru p 3 but respiratory allergy to Pru p 9: A large study group from a peach exposed population. PLoS One. 2021 Aug 19;16(8):e0255305
NO This work was supported by grants PI15/01317, PI17/00615 and PI20/00607 awarded by the Ministry of Economy and Competitiveness and the Institute of Health Carlos III, and co-funded by the European Regional Development Fund (ERDF) for the Thematic Networks and Co-operative Research Centres: ARADyAL (RD16/0006/0032, RD16/0006/0001 and RD16/0006/0024). It was also supported by Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud (FIMABIS). This study was supported in part by a research grant from Inmunotek SL.
DS RISalud
RD Apr 15, 2025