RT Journal Article
T1 Role of aquaporins in cell proliferation: What else beyond water permeability?
A1 Galán-Cobo, Ana
A1 Ramírez-Lorca, Reposo
A1 Echevarría, Miriam
K1 aquaporins (AQPs)
K1 cell cycle
K1 cell proliferation
K1 gene expression
K1 glycerol
K1 hydrogen peroxide permeability
K1 neurogenic niche
AB In addition to the extensive data demonstrating the importance of mammalian AQPs for the movement of water and some small solutes across the cell membrane, there is now a growing body of evidence indicating the involvement of these proteins in numerous cellular processes seemingly unrelated, at least some of them in a direct way, to their canonical function of water permeation. Here, we have presented a broad range of evidence demonstrating that these proteins have a role in cell proliferation by various different mechanisms, namely, by allowing fast cell volume regulation during cell division; by affecting progression of cell cycle and helping maintain the balance between proliferation and apoptosis, and by crosstalk with other cell membrane proteins or transcription factors that, in turn, modulate progression of the cell cycle or regulate biosynthesis pathways of cell structural components. In the end, however, after discussing all these data that strongly support a role for AQPs in the cell proliferation process, it remains impossible to conclude that all these other functions attributed to AQPs occur completely independently of their water permeability, and there is a need for new experiments designed specifically to address this interesting issue.
YR 2016
FD 2016-01-11
LK http://hdl.handle.net/10668/9721
UL http://hdl.handle.net/10668/9721
LA en
DS RISalud
RD Apr 5, 2025