RT Journal Article
T1 The association between SARS-CoV-2 infection and preterm delivery: a prospective study with a multivariable analysis.
A1 Martinez-Perez, Oscar
A1 Prats-Rodriguez, Pilar
A1 Muner-Hernandez, Marta
A1 Encinas-Pardilla, Maria Begoña
A1 Perez-Perez, Noelia
A1 Vila-Hernandez, Maria Rosa
A1 Villalba-Yarza, Ana
A1 Nieto-Velasco, Olga
A1 Del-Barrio-Fernandez, Pablo Guillermo
A1 Forcen-Acebal, Laura
A1 Orizales-Lago, Carmen Maria
A1 Martinez-Varea, Alicia
A1 Muñoz-Abellana, Begoña
A1 Suarez-Arana, Maria
A1 Fuentes-Ricoy, Laura
A1 Martinez-Diago, Clara
A1 Janeiro-Freire, Maria Jesus
A1 Alférez-Alvarez-Mallo, Macarena
A1 Casanova-Pedraz, Cristina
A1 Alomar-Mateu, Onofre
A1 Lesmes-Heredia, Cristina
A1 Wizner-de-Alva, Juan Carlos
A1 Bernardo-Vega, Rut
A1 Macia-Badia, Montserrat
A1 Alvarez-Colomo, Cristina
A1 Sanchez-Muñoz, Antonio
A1 Pratcorona-Alicart, Laia
A1 Alonso-Saiz, Ruben
A1 Lopez-Rodriguez, Monica
A1 Del-Carmen-Barbancho-Lopez, Maria
A1 Meca-Casbas, Marta Ruth
A1 Vaquerizo-Ruiz, Oscar
A1 Moran-Antolin, Eva
A1 Nuñez-Valera, Maria Jose
A1 Fernandez-Fernandez, Camino
A1 Tubau-Navarra, Albert
A1 Cano-Garcia, Alejandra Maria
A1 Baena-Luque, Carmen
A1 Soldevilla-Perez, Susana
A1 Gastaca-Abasolo, Irene
A1 Adanez-Garcia, Jose
A1 Teulon-Gonzalez, Maria
A1 Puertas-Prieto, Alberto
A1 Ostos-Serna, Rosa
A1 Del-Pilar-Guadix-Martin, Maria
A1 Catalina-Coello, Monica
A1 Ferriols-Perez, Elena
A1 Caño-Aguilar, Africa
A1 De-la-Cruz-Conty, Maria Luisa
A1 Sainz-Bueno, Jose Antonio
K1 COVID-19
K1 Coronavirus
K1 Intensive care units, neonatal
K1 Pregnancy
K1 Premature birth
K1 Premature rupture of membranes
K1 SARS-CoV-2
K1 Área de Gestión Sanitaria de Jerez, Costa Noroeste y Sierra de Cádiz
K1 Area de Gestión Sanitaria Sur de Córdoba
K1 Área de Gestión Sanitaria Sur de Sevilla
AB To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, the cause of COVID-19 disease) exposure in pregnancy, compared to non-exposure, is associated with infection-related obstetric morbidity. We conducted a multicentre prospective study in pregnancy based on a universal antenatal screening program for SARS-CoV-2 infection. Throughout Spain 45 hospitals tested all women at admission on delivery ward using polymerase-chain-reaction (PCR) for COVID-19 since late March 2020. The cohort of positive mothers and the concurrent sample of negative mothers was followed up until 6-weeks post-partum. Multivariable logistic regression analysis, adjusting for known confounding variables, determined the adjusted odds ratio (aOR) with 95% confidence intervals (95% CI) of the association of SARS-CoV-2 infection and obstetric outcomes. Preterm delivery (primary), premature rupture of membranes and neonatal intensive care unit admissions. Among 1009 screened pregnancies, 246 were SARS-CoV-2 positive. Compared to negative mothers (763 cases), SARS-CoV-2 infection increased the odds of preterm birth (34 vs 51, 13.8% vs 6.7%, aOR 2.12, 95% CI 1.32-3.36, p = 0.002); iatrogenic preterm delivery was more frequent in infected women (4.9% vs 1.3%, p = 0.001), while the occurrence of spontaneous preterm deliveries was statistically similar (6.1% vs 4.7%). An increased risk of premature rupture of membranes at term (39 vs 75, 15.8% vs 9.8%, aOR 1.70, 95% CI 1.11-2.57, p = 0.013) and neonatal intensive care unit admissions (23 vs 18, 9.3% vs 2.4%, aOR 4.62, 95% CI 2.43-8.94, p  This prospective multicentre study demonstrated that pregnant women infected with SARS-CoV-2 have more infection-related obstetric morbidity. This hypothesis merits evaluation of a causal association in further research.
PB BioMed Central
YR 2021
FD 2021-04-01
LK http://hdl.handle.net/10668/17435
UL http://hdl.handle.net/10668/17435
LA en
NO Martinez-Perez O, Prats Rodriguez P, Muner Hernandez M, Encinas Pardilla MB, Perez Perez N, Vila Hernandez MR, et al. The association between SARS-CoV-2 infection and preterm delivery: a prospective study with a multivariable analysis. BMC Pregnancy Childbirth. 2021 Apr 1;21(1):273
NO This project was supported by public funds obtained in competitive calls: Grant COV20/00021 from the Institute of Health- Carlos III and co-financed with Fondo Europeo de Desarrollo Regional (FEDER) funds.
DS RISalud
RD Apr 7, 2025