%0 Journal Article
%A Martinez-Perez, Oscar
%A Prats-Rodriguez, Pilar
%A Muner-Hernandez, Marta
%A Encinas-Pardilla, Maria Begoña
%A Perez-Perez, Noelia
%A Vila-Hernandez, Maria Rosa
%A Villalba-Yarza, Ana
%A Nieto-Velasco, Olga
%A Del-Barrio-Fernandez, Pablo Guillermo
%A Forcen-Acebal, Laura
%A Orizales-Lago, Carmen Maria
%A Martinez-Varea, Alicia
%A Muñoz-Abellana, Begoña
%A Suarez-Arana, Maria
%A Fuentes-Ricoy, Laura
%A Martinez-Diago, Clara
%A Janeiro-Freire, Maria Jesus
%A Alférez-Alvarez-Mallo, Macarena
%A Casanova-Pedraz, Cristina
%A Alomar-Mateu, Onofre
%A Lesmes-Heredia, Cristina
%A Wizner-de-Alva, Juan Carlos
%A Bernardo-Vega, Rut
%A Macia-Badia, Montserrat
%A Alvarez-Colomo, Cristina
%A Sanchez-Muñoz, Antonio
%A Pratcorona-Alicart, Laia
%A Alonso-Saiz, Ruben
%A Lopez-Rodriguez, Monica
%A Del-Carmen-Barbancho-Lopez, Maria
%A Meca-Casbas, Marta Ruth
%A Vaquerizo-Ruiz, Oscar
%A Moran-Antolin, Eva
%A Nuñez-Valera, Maria Jose
%A Fernandez-Fernandez, Camino
%A Tubau-Navarra, Albert
%A Cano-Garcia, Alejandra Maria
%A Baena-Luque, Carmen
%A Soldevilla-Perez, Susana
%A Gastaca-Abasolo, Irene
%A Adanez-Garcia, Jose
%A Teulon-Gonzalez, Maria
%A Puertas-Prieto, Alberto
%A Ostos-Serna, Rosa
%A Del-Pilar-Guadix-Martin, Maria
%A Catalina-Coello, Monica
%A Ferriols-Perez, Elena
%A Caño-Aguilar, Africa
%A De-la-Cruz-Conty, Maria Luisa
%A Sainz-Bueno, Jose Antonio
%T The association between SARS-CoV-2 infection and preterm delivery: a prospective study with a multivariable analysis.
%D 2021
%U http://hdl.handle.net/10668/17435
%X To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, the cause of COVID-19 disease) exposure in pregnancy, compared to non-exposure, is associated with infection-related obstetric morbidity. We conducted a multicentre prospective study in pregnancy based on a universal antenatal screening program for SARS-CoV-2 infection. Throughout Spain 45 hospitals tested all women at admission on delivery ward using polymerase-chain-reaction (PCR) for COVID-19 since late March 2020. The cohort of positive mothers and the concurrent sample of negative mothers was followed up until 6-weeks post-partum. Multivariable logistic regression analysis, adjusting for known confounding variables, determined the adjusted odds ratio (aOR) with 95% confidence intervals (95% CI) of the association of SARS-CoV-2 infection and obstetric outcomes. Preterm delivery (primary), premature rupture of membranes and neonatal intensive care unit admissions. Among 1009 screened pregnancies, 246 were SARS-CoV-2 positive. Compared to negative mothers (763 cases), SARS-CoV-2 infection increased the odds of preterm birth (34 vs 51, 13.8% vs 6.7%, aOR 2.12, 95% CI 1.32-3.36, p = 0.002); iatrogenic preterm delivery was more frequent in infected women (4.9% vs 1.3%, p = 0.001), while the occurrence of spontaneous preterm deliveries was statistically similar (6.1% vs 4.7%). An increased risk of premature rupture of membranes at term (39 vs 75, 15.8% vs 9.8%, aOR 1.70, 95% CI 1.11-2.57, p = 0.013) and neonatal intensive care unit admissions (23 vs 18, 9.3% vs 2.4%, aOR 4.62, 95% CI 2.43-8.94, p  This prospective multicentre study demonstrated that pregnant women infected with SARS-CoV-2 have more infection-related obstetric morbidity. This hypothesis merits evaluation of a causal association in further research.
%K COVID-19
%K Coronavirus
%K Intensive care units, neonatal
%K Pregnancy
%K Premature birth
%K Premature rupture of membranes
%K SARS-CoV-2
%K Área de Gestión Sanitaria de Jerez, Costa Noroeste y Sierra de Cádiz
%K Area de Gestión Sanitaria Sur de Córdoba
%K Área de Gestión Sanitaria Sur de Sevilla
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