RT Journal Article
T1 Developing collaborative works for faster progress on fungal respiratory infections in cystic fibrosis.
A1 Schwarz, Carsten
A1 Vandeputte, Patrick
A1 Rougeron, Amandine
A1 Giraud, Sandrine
A1 Dugé de Bernonville, Thomas
A1 Duvaux, Ludovic
A1 Gastebois, Amandine
A1 Alastruey-Izquierdo, Ana
A1 Martín-Gomez, Maria Teresa
A1 Mazuelos, Estrella Martin
A1 Sole, Amparo
A1 Cano, Josep
A1 Pemán, Javier
A1 Quindos, Guillermo
A1 Botterel, Françoise
A1 Bougnoux, Marie-Elisabeth
A1 Chen, Sharon
A1 Delhaès, Laurence
A1 Favennec, Loïc
A1 Ranque, Stéphane
A1 Sedlacek, Ludwig
A1 Steinmann, Joerg
A1 Vazquez, Jose
A1 Williams, Craig
A1 Meyer, Wieland
A1 Le Gal, Solène
A1 Nevez, Gilles
A1 Fleury, Maxime
A1 Papon, Nicolas
A1 Symoens, Françoise
A1 Bouchara, Jean-Philippe
A1 ECMM/ISHAM working group Fungal respiratory infections in Cystic
                    Fibrosis (Fri-CF), 
AB Cystic fibrosis (CF) is the major genetic inherited disease in Caucasian populations. The respiratory tract of CF patients displays a sticky viscous mucus, which allows for the entrapment of airborne bacteria and fungal spores and provides a suitable environment for growth of microorganisms, including numerous yeast and filamentous fungal species. As a consequence, respiratory infections are the major cause of morbidity and mortality in this clinical context. Although bacteria remain the most common agents of these infections, fungal respiratory infections have emerged as an important cause of disease. Therefore, the International Society for Human and Animal Mycology (ISHAM) has launched a working group on Fungal respiratory infections in Cystic Fibrosis (Fri-CF) in October 2006, which was subsequently approved by the European Confederation of Medical Mycology (ECMM). Meetings of this working group, comprising both clinicians and mycologists involved in the follow-up of CF patients, as well as basic scientists interested in the fungal species involved, provided the opportunity to initiate collaborative works aimed to improve our knowledge on these infections to assist clinicians in patient management. The current review highlights the outcomes of some of these collaborative works in clinical surveillance, pathogenesis and treatment, giving special emphasis to standardization of culture procedures, improvement of species identification methods including the development of nonculture-based diagnostic methods, microbiome studies and identification of new biological markers, and the description of genotyping studies aiming to differentiate transient carriage and chronic colonization of the airways. The review also reports on the breakthrough in sequencing the genomes of the main Scedosporium species as basis for a better understanding of the pathogenic mechanisms of these fungi, and discusses treatment options of infections caused by multidrug resistant microorganisms, such as Scedosporium and Lomentospora species and members of the Rasamsonia argillacea species complex.
YR 2018
FD 2018
LK http://hdl.handle.net/10668/12239
UL http://hdl.handle.net/10668/12239
LA en
DS RISalud
RD Apr 7, 2025