RT Journal Article
T1 Assisted reproductive technology and obstetric outcome in couples when the male partner has a chronic viral disease.
A1 Molina, Irene
A1 Gonzalvo, María del Carmen
A1 Clavero, Ana
A1 López-Ruz, Miguel Angel
A1 Mozas, Juan
A1 Pasquau, Juan
A1 Sampedro, Antonio
A1 Martínez, Luis
A1 Castilla, José Antonio
K1 HIV
K1 HCV
K1 HBV
K1 Reproductive techniques
K1 Obstetric labor complications
K1 Infecciones por VIH
K1 Fertilidad
K1 Seropositividad para VIH
K1 Técnicas reproductivas
K1 Complicaciones del trabajo de parto
K1 Inyecciones de esperma intracitoplasmáticas
K1 Anticuerpos contra la Hepatitis h
K1 Anticuerpos contra la hepatitis C
AB BACKGROUNDAssisted reproductive technology (ART) with washed semen can achieve pregnancy with minimal risk of horizontal and vertical transmission of chronic viral diseases (CVD) such as human immunodeficiency virus (HIV), hepati- tis C virus (HCV) and hepatitis B virus (HBV) among serodiscordant couples. How- ever, few studies have been made of the use made by these couples of ARTs or of the obstetric results achieved.MATERIALS AND METHODSIn this retrospective study, 93 men who were seropositive for HIV, HCV or HBV and who underwent assisted reproduction treatment at our centre (Hospital Universitario Virgen de las Nieves, Granada, Spain) were included. Washed semen was tested to detect viral particles. Non-infected women were tested before and after each treatment, as were the neonates at birth and after three months.RESULTSA total of 62 sperm samples were washed, and none were positive for the detec- tion of viral molecules. Semen samples from 34 HBV positive males were not washed since the female partner had immunity to hepatitis B. In total, 38 clinical pregnancies were achieved (22% per cycle and 40.9% per couple) out of 173 cycles initiated, and 28 births were achieved (16.2% per cycle and 30.1% per couple), producing 34 live births. The rate of multiple pregnancies was 21.4%. Obstetric and neonatal results were similar in the groups of couples studied. At follow-up, no seroconversion was detected in the women or neonates.CONCLUSIONSperm washing and intracytoplasmic sperm injection are shown to be a safe and effective option for reducing the risk of transmission or super infection in serodiscordant or concordant couples who wish to have a child. Pregnancies ob- tained by ART in couples when the male is CVD infected achieve good obstetric and neonatal results.
PB Royan Institute (ACECR), Tehran
SN 2008-0778
YR 2014
FD 2014-01
LK http://hdl.handle.net/10668/1648
UL http://hdl.handle.net/10668/1648
LA en
NO Molina I, Gonzalvo MC, Clavero A,  López-Ruz MA, Mozas J, Pasquau J, et al. Assisted reproductive technology and obstetric outcome in couples when the male partner has a chronic viral disease. Int J Fertil Steril . 2014 Jan-Mar; 7(4): 291–300
NO Journal Article;
DS RISalud
RD Apr 5, 2025