RT Journal Article
T1 Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users.
A1 Luciano-Mateo, Fedra
A1 Hernández-Aguilera, Anna
A1 Cabre, Noemi
A1 Camps, Jordi
A1 Fernández-Arroyo, Salvador
A1 Lopez-Miranda, Jose
A1 Menendez, Javier A
A1 Joven, Jorge
K1 diabetes mellitus
K1 energy intake
K1 epigenetics
K1 folic acid
K1 food source
K1 food-drug interactions
K1 obesity
K1 vitamins B
AB Metabolic vulnerability is associated with age-related diseases and concomitant co-morbidities, which include obesity, diabetes, atherosclerosis and cancer. Most of the health problems we face today come from excessive intake of nutrients and drugs mimicking dietary effects and dietary restriction are the most successful manipulations targeting age-related pathways. Phenotypic heterogeneity and individual response to metabolic stressors are closely related food intake. Understanding the complexity of the relationship between dietary provision and metabolic consequences in the long term might provide clinical strategies to improve healthspan. New aspects of metformin activity provide a link to many of the overlapping factors, especially the way in which organismal bioenergetics remodel one-carbon metabolism. Metformin not only inhibits mitochondrial complex 1, modulating the metabolic response to nutrient intake, but also alters one-carbon metabolic pathways. Here, we discuss findings on the mechanism(s) of action of metformin with the potential for therapeutic interpretations.
YR 2017
FD 2017-02-10
LK https://hdl.handle.net/10668/25675
UL https://hdl.handle.net/10668/25675
LA en
DS RISalud
RD Apr 12, 2025