RT Journal Article
T1 Assessing the antioxidant and metabolic effect of an alpha-lipoic acid and acetyl-L-carnitine nutraceutical
A1 Lopez-Maldonado, Alicia
A1 Pastoriza, Silvia
A1 Rufián-Henares, José Ángel
K1 Alpha-lipoic acid
K1 Acetyl-L-carnitine
K1 Nutraceutical
K1 Antioxidant
K1 Pilot study
K1 Oxidative stress
K1 Ácido tióctico
K1 Acetilcarnitina
K1 Suplementos dietéticos
K1 Antioxidantes
K1 Proyectos piloto
K1 Estrés oxidativo
AB Personalized nutrition (PN) is seen as a potentially effective and affordable strategy for the prevention of non-communicable diseases (NCDs). In this study we aimed to evaluate the antioxidant and metabolic effect of a dietary supplement based on alpha-lipoic acid (ALA) and acetyl-L-carnitine (ALC) in order to include this product in a novel PN service. The antioxidant properties of the commercial nutraceutical were investigated at physiological conditions (through in vitro digestion) and at mitochondrial conditions. The metabolic activity was assessed in a human pilot study using a Gas Chromatography-Mass Spectrometry (GC-MS) methodology in dried urine samples. The nutraceutical exerted an elevated antiradical activity and reducing capacity, especially at mitochondrial conditions, after in vitro digestion. This increase in mitochondrial activity was also evidenced in vivo by a significant increase in the urinary phosphate concentration (p ​= ​0.004). As pro-oxidant effect was reached with the concentration of 4 capsules, 2 capsules at the same time could be a reasonable dose. No adverse effects were recorded in vivo with this dose. Thus, although its metabolic effect was not so conclusive, ALA ​+ ​ALC combination might be beneficial as a dietary supplement for the prevention of the oxidative stress and an interesting dietary supplement to consider in large scale studies.
PB Elsevier B.V.
YR 2021
FD 2021
LK http://hdl.handle.net/10668/4095
UL http://hdl.handle.net/10668/4095
LA en
NO Lopez-Maldonado A, Pastoriza S, Rufián-Henares JÁ. Assessing the antioxidant and metabolic effect of an alpha-lipoic acid and acetyl-L-carnitine nutraceutical. Curr Res Food Sci. 2021 May 28;4:336-344.
DS RISalud
RD Apr 5, 2025