RT Journal Article
T1 Lidocaine Pharmaceutical Multicomponent Forms: A Story about the Role of Chloride Ions on Their Stability
A1 Verdugo-Escamilla, Cristobal
A1 Alarcon-Payer, Carolina
A1 Acebedo-Martinez, Francisco Javier
A1 Fernandez-Penas, Raquel
A1 Dominguez-Martin, Alicia
A1 Choquesillo-Lazarte, Duane
K1 lidocaine
K1 cocrystals
K1 mechanochemistry
K1 multicomponent materials
K1 API
K1 pharmaceutical solids
K1 solubility
K1 Pharmacology
K1 Prediction
K1 Salts
AB In this investigation, three new crystal forms of lidocaine, and another three of lidocaine hydrochloride with hydroquinone, resorcinol, and pyrogallol were synthetised. All the new forms were characterised using multiple techniques, PXRD, SC-XRD, DSC, and FTIR. The stability of the forms was studied, and, for the more stable forms, i.e., (lidhcl) forms, the solubility was determined through FTIR analysis. The new crystalline forms obtained with (lidhcl) and the three coformers showed an interesting steric stabilisation mechanism of the oxidation of hydroxybenzenes and showed good physicochemical properties with respect to (lidhcl), constituting a mechanism of modulation of the physicochemical properties.
PB Mdpi
YR 2022
FD 2022-06-01
LK http://hdl.handle.net/10668/20950
UL http://hdl.handle.net/10668/20950
LA en
DS RISalud
RD Apr 18, 2025