TY  - JOUR
AU  - Mahmoud, Ayman M
AU  - Wilkinson, Fiona L
AU  - Jones, Alan M
AU  - Wilkinson, James A
AU  - Romero, Miguel
AU  - Duarte, Juan
AU  - Alexander, M Yvonne
PY  - 2016
DO  - 10.1016/j.bbagen.2016.08.013
SN  - 0304-4165
UR  - http://hdl.handle.net/10668/10387
T2  - Biochimica et biophysica acta. General subjects
AB  - Glycomimetics are a diverse array of saccharide-inspired compounds, designed to mimic the bioactive functions of glycosaminoglycans. Therefore, glycomimetics represent a unique source of novel therapies to target aberrant signaling and protein...
LA  - en
PB  - Elsevier BV
KW  - Endothelial dysfunction
KW  - Glycomimetics
KW  - Heparan sulfate
KW  - Oxidative stress
KW  - Small molecule drug discovery
KW  - Animals
KW  - Antioxidant Response Elements
KW  - Aorta
KW  - Cell Survival
KW  - Endothelium, Vascular
KW  - Human Umbilical Vein Endothelial Cells
KW  - Lipids
KW  - Male
KW  - Mice, Inbred BALB C
KW  - Models, Biological
KW  - NADPH Oxidases
KW  - NF-E2-Related Factor 2
KW  - Nitric Oxide
KW  - Nitric Oxide Synthase Type III
KW  - Oxidative Stress
KW  - Palmitic Acid
KW  - Phosphorylation
KW  - Polysaccharides
KW  - Protective Agents
KW  - Proto-Oncogene Proteins c-akt
KW  - RNA, Messenger
KW  - Reactive Oxygen Species
KW  - Signal Transduction
KW  - Small Molecule Libraries
KW  - Vasodilation
TI  - A novel role for small molecule glycomimetics in the protection against lipid-induced endothelial dysfunction: Involvement of Akt/eNOS and Nrf2/ARE signaling.
TY  - research article
VL  - 1861
ER  -