RT Journal Article
T1 Pancreatic Cancer Risk in Relation to Lifetime Smoking Patterns, Tobacco Type, and Dose-Response Relationships.
A1 Molina-Montes, Esther
A1 Van Hoogstraten, Lisa
A1 Gomez-Rubio, Paulina
A1 Löhr, Matthias
A1 Sharp, Linda
A1 Molero, Xavier
A1 Márquez, Mirari
A1 Michalski, Christoph W
A1 Farré, Antoni
A1 Perea, José
A1 O'Rorke, Michael
A1 Greenhalf, William
A1 Ilzarbe, Lucas
A1 Tardon, Adonina
A1 Gress, Thomas M
A1 Barberà, Victor M
A1 Crnogorac-Jurcevic, Tatjana
A1 Muñoz-Bellvis, Luis
A1 Domínguez-Muñoz, Enrique
A1 Balsells, Joaquim
A1 Costello, Eithne
A1 Iglesias, Mar
A1 Kleeff, Jorg
A1 Kong, Bo
A1 Mora, Josefina
A1 O'Driscoll, Damian
A1 Poves, Ignasi
A1 Scarpa, Aldo
A1 Yu, Jingru
A1 Ye, Weimin
A1 Hidalgo, Manuel
A1 Carrato, Alfredo
A1 Lawlor, Rita
A1 Real, Francisco X
A1 Malats, Nuria
A1 PanGenEU Study Investigators, 
AB Despite smoking being a well-established risk factor for pancreatic cancer, there is a need to further characterize pancreatic cancer risk according to lifespan smoking patterns and other smoking features, such as tobacco type. Our aim was to deeply investigate them within a large European case-control study. Tobacco smoking habits and other relevant information were obtained from 2,009 cases and 1,532 controls recruited in the PanGenEU study using standardized tools. Multivariate logistic regression analysis was performed to evaluate pancreatic cancer risk by smoking characteristics and interactions with other pancreatic cancer risk factors. Fractional polynomials and restricted cubic splines were used to test for nonlinearity of the dose-response relationships and to analyze their shape. Relative to never-smokers, current smokers [OR = 1.72; 95% confidence interval (95% CI), 1.39-2.12], those inhaling into the throat (OR = 1.48; 95% CI, 1.11-1.99) or chest (OR = 1.33; 95% CI, 1.12-1.58), and those using nonfiltered cigarettes (OR = 1.69; 95% CI, 1.10-2.61), were all at an increased pancreatic cancer risk. Pancreatic cancer risk was highest in current black tobacco smokers (OR = 2.09; 95% CI, 1.31-3.41), followed by blond tobacco smokers (OR = 1.43; 95% CI, 1.01-2.04). Childhood exposure to tobacco smoke relative to parental smoking was also associated with increased pancreatic cancer risk (OR = 1.24; 95% CI, 1.03-1.49). Dose-response relationships for smoking duration, intensity, cumulative dose, and smoking cessation were nonlinear and showed different shapes by tobacco type. Effect modification by family history of pancreatic cancer and diabetes was likely. This study reveals differences in pancreatic cancer risk by tobacco type and other habit characteristics, as well as nonlinear risk associations. This characterization of smoking-related pancreatic cancer risk profiles may help in defining pancreatic cancer high-risk populations.
YR 2020
FD 2020-02-12
LK https://hdl.handle.net/10668/24920
UL https://hdl.handle.net/10668/24920
LA en
DS RISalud
RD Apr 14, 2025