RT Journal Article
T1 A comprehensive database for integrated analysis of omics data in autoimmune diseases
A1 Martorell-Marugán, Jordi
A1 López-Domínguez, Raúl
A1 García-Moreno, Adrián
A1 Toro-Domínguez, Daniel
A1 Villatoro-García, Juan Antonio
A1 Barturen, Guillermo
A1 Martín-Gómez, Adoración
A1 Troule, Kevin
A1 Gómez-López, Gonzalo
A1 Al-Shahrour, Fátima
A1 González-Rumayor, Víctor
A1 Peña-Chilet, María
A1 Dopazo, Joaquín
A1 Sáez-Rodríguez, Julio
A1 Alarcón-Riquelme, Marta E.
A1 Carmona-Sáez, Pedro
K1 Autoimmune disease
K1 Database
K1 GEO
K1 Transcriptomics
K1 Epigenomics
K1 Curation
K1 Dataset
K1 Interferon signature
K1 Gene expression
K1 Meta-analysis
K1 Enfermedades autoinmunes
K1 Base de datos
K1 Epigenómica
K1 Conjunto de datos
K1 Expresión génica
K1 Metaanálisis
AB Background: Autoimmune diseases are heterogeneous pathologies with difcult diagnosis and few therapeutic options. In the last decade, several omics studies have provided signifcant insights into the molecular mechanisms of these diseases. Never‑theless, data from diferent cohorts and pathologies are stored independently in public repositories and a unifed resource is imperative to assist researchers in this feld.Results: Here, we present Autoimmune Diseases Explorer (https://adex.genyo.es), a database that integrates 82 curated transcriptomics and methylation studies cover‑ing 5609 samples for some of the most common autoimmune diseases. The data‑base provides, in an easy-to-use environment, advanced data analysis and statistical methods for exploring omics datasets, including meta-analysis, diferential expression or pathway analysis.Conclusions: This is the frst omics database focused on autoimmune diseases. This resource incorporates homogeneously processed data to facilitate integrative analyses among studies.
PB BioMed Central, Springer Nature
YR 2021
FD 2021-06-24
LK http://hdl.handle.net/10668/3807
UL http://hdl.handle.net/10668/3807
LA en
NO Martorell-Marugán J, López-Domínguez R, García-Moreno A, Toro-Domínguez D, Villatoro-García JA, Barturen G, et al. A comprehensive database for integrated analysis of omics data in autoimmune diseases. BMC Bioinformatics. 2021 Jun 24;22(1):343
DS RISalud
RD Apr 9, 2025