RT Journal Article
T1 High risk of subclinical atherosclerosis in COPD exacerbator phenotype.
A1 Domenech, Adolfo
A1 Muñoz-Montiel, Ana
A1 Garcia-Casares, Natalia
A1 Rioja, Jose
A1 Ruiz-Esteban, Pedro
A1 Gutierrez-Castaño, Patricia
A1 Prunera-Pardell, María Jesus
A1 Olveira, Casilda
A1 Valdivielso, Pedro
A1 Sanchez-Chaparro, Miguel Angel
K1 Atherosclerosis
K1 COPD
K1 COPD exacerbation
K1 Cardiovascular risk
K1 Phenotype
AB It is not known whether COPD exacerbations contribute to an increased vascular risk already associated with the disease. For this reason, we prospectively evaluated 127 patients referred for a monographic COPD consultation. We classify as exacerbators those who had experienced two or more moderate exacerbations in the previous year, or who had had a hospital admission. All underwent a blood analysis, respiratory function tests, global cardiovascular and coronary risk estimates (with four of the most frequently used scores, and the Chronic Obstructive Pulmonary Disease Coronaropathy Risk (COPDCoRi) score, respectively); and an EcoDoppler to measure carotid intima-media thickness and the ankle-brachial index. Finally, we included 50 patients with exacerbator phenotypes and 57 with non-exacerbator phenotypes, ranging from 63 ± 7 years old, 74% of whom were male. The exacerbator phenotype increased the risk of carotid intima-media thickness above the 75th percentile range by a factor of almost three, independently of the severity of COPD and global cardiovascular risk. The association between the exacerbator phenotype and high c-IMT was more evident in patients under 65. In conclusion, the presence of subclinical atherosclerosis is independently associated with the exacerbator phenotype, with more pronounced differences in younger patient; which suggests that we should intensify control of vascular risk factors in these groups of patients.
PB Elsevier
YR 2018
FD 2018-07-17
LK http://hdl.handle.net/10668/12766
UL http://hdl.handle.net/10668/12766
LA en
NO Domenech A, Muñoz-Montiel A, García-Casares N, Rioja J, Ruiz-Esteban P, Gutierrez-Castaño P, et al. High risk of subclinical atherosclerosis in COPD exacerbator phenotype. Respir Med. 2018 Aug;141:165-171
NO NEUMOSUR 9/2013, SEPAR 110/2014, Menarini Group, Ibermutuamur FIS PI12/02812, PAIDI CTS-159 Group.
DS RISalud
RD Jul 29, 2025