%0 Journal Article
%A Domenech, Adolfo
%A Muñoz-Montiel, Ana
%A Garcia-Casares, Natalia
%A Rioja, Jose
%A Ruiz-Esteban, Pedro
%A Gutierrez-Castaño, Patricia
%A Prunera-Pardell, María Jesus
%A Olveira, Casilda
%A Valdivielso, Pedro
%A Sanchez-Chaparro, Miguel Angel
%T High risk of subclinical atherosclerosis in COPD exacerbator phenotype.
%D 2018
%U http://hdl.handle.net/10668/12766
%X It is not known whether COPD exacerbations contribute to an increased vascular risk already associated with the disease. For this reason, we prospectively evaluated 127 patients referred for a monographic COPD consultation. We classify as exacerbators those who had experienced two or more moderate exacerbations in the previous year, or who had had a hospital admission. All underwent a blood analysis, respiratory function tests, global cardiovascular and coronary risk estimates (with four of the most frequently used scores, and the Chronic Obstructive Pulmonary Disease Coronaropathy Risk (COPDCoRi) score, respectively); and an EcoDoppler to measure carotid intima-media thickness and the ankle-brachial index. Finally, we included 50 patients with exacerbator phenotypes and 57 with non-exacerbator phenotypes, ranging from 63 ± 7 years old, 74% of whom were male. The exacerbator phenotype increased the risk of carotid intima-media thickness above the 75th percentile range by a factor of almost three, independently of the severity of COPD and global cardiovascular risk. The association between the exacerbator phenotype and high c-IMT was more evident in patients under 65. In conclusion, the presence of subclinical atherosclerosis is independently associated with the exacerbator phenotype, with more pronounced differences in younger patient; which suggests that we should intensify control of vascular risk factors in these groups of patients.
%K Atherosclerosis
%K COPD
%K COPD exacerbation
%K Cardiovascular risk
%K Phenotype
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