RT Journal Article
T1 Survival analysis and sentinel lymph node status in thin cutaneous melanoma: A multicenter observational study.
A1 Tejera-Vaquerizo, Antonio
A1 Ribero, Simone
A1 Puig, Susana
A1 Boada, Aram
A1 Paradela, Sabela
A1 Moreno-Ramírez, David
A1 Cañueto, Javier
A1 de Unamuno, Blanca
A1 Brinca, Ana
A1 Descalzo-Gallego, Miguel A
A1 Osella-Abate, Simona
A1 Cassoni, Paola
A1 Carrera, Cristina
A1 Vidal-Sicart, Sergi
A1 Bennássar, Antoni
A1 Rull, Ramón
A1 Alos, Llucìa
A1 Requena, Celia
A1 Bolumar, Isidro
A1 Traves, Víctor
A1 Pla, Ángel
A1 Fernández-Orland, A
A1 Jaka, Ane
A1 Fernández-Figueres, María T
A1 Hilari, Josep M
A1 Giménez-Xavier, Pol
A1 Vieira, Ricardo
A1 Botella-Estrada, Rafael
A1 Román-Curto, Concepción
A1 Ferrándiz, Lara
A1 Iglesias-Pena, Nicolás
A1 Ferrándiz, Carlos
A1 Malvehy, Josep
A1 Quaglino, Pietro
A1 Nagore, Eduardo
A1 SENTIMEL group, 
K1 Cox proportional hazards regression analysis
K1 age factors
K1 melanoma
K1 mitotic index
K1 multiple imputation
K1 neoplasia staging
K1 prognostic factors
K1 sentinel lymph node biopsy
K1 survival
AB Mitotic rate is no longer considered a staging criterion for thin melanoma in the 8th edition of the American Joint Committee on Cancer Staging Manual. The aim of this observational study was to identify prognostic factors for thin melanoma and predictors and prognostic significance of sentinel lymph node (SLN) involvement in a large multicenter cohort of patients with melanoma from nine tertiary care hospitals. A total of 4249 consecutive patients with thin melanoma diagnosed from January 1, 1998 to December 31, 2016 were included. The main outcomes were disease-free interval and melanoma-specific survival for the overall population and predictors of SLN metastasis (n = 1083). Associations between survival and SLN status and different clinical and pathologic variables (sex, age, tumor location, mitosis, ulceration, regression, lymphovascular invasion, histologic subtype, Clark level, and Breslow thickness) were analyzed by Cox proportional hazards regression and logistic regression. SLN status was the most important prognostic factor for melanoma-specific survival (hazard ratio, 13.8; 95% CI, 6.1-31.2; P 2 mitoses/mm2 was the only factor associated with a positive SLN biopsy (odds ratio, 2.9; 95% CI, 1.22-7; P = 0.01. SLN status is the most important prognostic factor in thin melanoma. A high mitotic rate is associated with metastatic SLN involvement. SLN biopsy should be discussed and recommended in patients with thin melanoma and a high mitotic rate.
YR 2019
FD 2019-06-18
LK http://hdl.handle.net/10668/14139
UL http://hdl.handle.net/10668/14139
LA en
DS RISalud
RD Apr 8, 2025