RT Journal Article
T1 An extended reconstruction of human gut microbiota metabolism of dietary compounds
A1 Blasco, Telmo
A1 Pérez-Burillo, Sergio
A1 Balzerani, Francesco
A1 Hinojosa-Nogueira, Daniel
A1 Lerma-Aguilera, Alberto
A1 Pastoriza, Silvia
A1 Cendoya, Xabier
A1 Rubio, Ángel
A1 Gosalbes, María José
A1 Jiménez-Hernández, Nuria
A1 Francino, M. Pilar
A1 Apaolaza, Iñigo
A1 Rufián-Henares, José Ángel
A1 Planes, Francisco J.
K1 Child
K1 16S rRNA
K1 Diet
K1 Fermentation
K1 In vitro
K1 Dieta
K1 Niño
K1 RNA, Ribosomal, 16S
K1 Dieta
K1 Fermentación
K1 Técnicas in vitro
AB Understanding how diet and gut microbiota interact in the context of human health is a key question in personalized nutrition. Genome-scale metabolic networks and constraint-based modeling approaches are promising to systematically address this complex problem. However, when applied to nutritional questions, a major issue in existing reconstructions is the limited information about compounds in the diet that are metabolized by the gut microbiota. Here, we present AGREDA, an extended reconstruction of diet metabolism in the human gut microbiota. AGREDA adds the degradation pathways of 209 compounds present in the human diet, mainly phenolic compounds, a family of metabolites highly relevant for human health and nutrition. We show that AGREDA outperforms existing reconstructions in predicting diet-specific output metabolites from the gut microbiota. Using 16S rRNA gene sequencing data of faecal samples from Spanish children representing different clinical conditions, we illustrate the potential of AGREDA to establish relevant metabolic interactions between diet and gut microbiota.
PB Springer Nature
YR 2021
FD 2021-08-05
LK http://hdl.handle.net/10668/4192
UL http://hdl.handle.net/10668/4192
LA en
NO Blasco T, Pérez-Burillo S, Balzerani F, Hinojosa-Nogueira D, Lerma-Aguilera A, Pastoriza S, et al. An extended reconstruction of human gut microbiota metabolism of dietary compounds. Nat Commun. 2021 Aug 5;12(1):4728.
DS RISalud
RD Apr 7, 2025