RT Journal Article
T1 You might owe your mother more than you think.
A1 de-Las-Vecillas, Leticia
A1 Eguiluz-Gracia, Ibon
A1 Giovannini, Mattia
K1 IgE
K1 Mast cells
K1 Protection
K1 Toxin hypothesis
K1 Transplacental transfer
AB Immunoglobulin E (IgE)–mediated activation of mast cells (MC) has been historically linked to allergic reactions. Nevertheless, antibody-dependent MC degranulation can also be triggered by venoms from insects or reptiles. Of note, MC mediators provide efficient protection against the toxic compounds of venoms. Interestingly, antigen-specific (s) IgE-dependent MC activation could occur in newborns who are not able yet to mount functional antibody responses. In a recent article, Msallam et al. investigated the interactions among fetal MC, maternal sIgE, and fetal immune responses in mice and humans. Mouse fetal MC acquire a semi-mature phenotype according to their FcεRI and heparin expression levels, and increase in number during early development stages.
PB Wiley
YR 2021
FD 2021-04-08
LK http://hdl.handle.net/10668/17560
UL http://hdl.handle.net/10668/17560
LA en
NO de Las Vecillas L, Eguiluz-Gracia I, Giovannini M. You might owe your mother more than you think. Allergy. 2021 Oct;76(10):3236-3237
NO This work was supported by the Instituto de Salud Carlos III of the Spanish Ministry of Science and Competitiveness (grants co-funded by theEuropean Regional Development Fund) through the research contract “Juan Rodes” for IEG (JR19/00029), and the program of RedesTemáticas deInvestigaciónColaborativaenSalud (RETICS): Asma, ReaccionesAdversas y Alérgicas-ARADyAL (RD16/0006/0001).
DS RISalud
RD Apr 6, 2025