TY  - JOUR
AU  - Larkin, James
AU  - Ascierto, Paolo A
AU  - Dréno, Brigitte
AU  - Atkinson, Victoria
AU  - Liszkay, Gabriella
AU  - Maio, Michele
AU  - Mandalà, Mario
AU  - Demidov, Lev
AU  - Stroyakovskiy, Daniil
AU  - Thomas, Luc
AU  - de la Cruz-Merino, Luis
AU  - Dutriaux, Caroline
AU  - Garbe, Claus
AU  - Sovak, Mika A
AU  - Chang, Ilsung
AU  - Choong, Nicholas
AU  - Hack, Stephen P
AU  - McArthur, Grant A
AU  - Ribas, Antoni
PY  - 2014
DO  - 10.1056/NEJMoa1408868
SN  - 0028-4793
UR  - http://hdl.handle.net/10668/2159
T2  - The New England journal of medicine
AB  - BACKGROUNDThe combined inhibition of BRAF and MEK is hypothesized to improve clinical outcomes in patients with melanoma by preventing or delaying the onset of resistance observed with BRAF inhibitors alone. This randomized phase 3 study evaluated the...
LA  - en
PB  - Massachusetts Medical Society
KW  - Indoles
KW  - Sulfonamides
KW  - Proto-oncogene proteins B-raf
KW  - MAP quinasa quinasa 1
KW  - Azetidines
KW  - Piperidinas
KW  - Sulfonamidas
KW  - Azetidinas
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Clinical Protocols::Antineoplastic Protocols::Antineoplastic Combined Chemotherapy Protocols
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Azetines::Azetidines
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Disease-Free Survival
KW  - Medical Subject Headings::Check Tags::Female
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Indoles
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Survival Analysis::Kaplan-Meier Estimate
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::Mitogen-Activated Protein Kinase...
KW  - Medical Subject Headings::Check Tags::Male
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Nevi and Melanomas::Melanoma
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Piperidines
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins::Oncogene Proteins::Proto-Oncogene Proteins::raf Kinases::Proto-Oncogene Proteins B-raf
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Sulfones::Sulfonamides
KW  - Medical Subject Headings::Information Science::Information Science::Data Collection::Vital Statistics::Mortality::Survival Rate
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
TI  - Combined vemurafenib and cobimetinib in BRAF-mutated melanoma.
TY  - research article
ER  -