TY  - JOUR
AU  - Pajares, María A.
AU  - Zimmerman, Tahl
AU  - Sánchez-Gómez, Francisco J.
AU  - Ariza, Adriana
AU  - Torres, María J.
AU  - Blanca, Miguel
AU  - Cañada, F. Javier
AU  - Montañez, María I.
AU  - Pérez-Sala, Dolores
PY  - 2020
DO  - 10.3389/fphar.2020.00189
UR  - http://hdl.handle.net/10668/3543
T2  - Frontiers in Pharmacology
AB  - Serum and cellular proteins are targets for the formation of adducts with the β-lactam antibiotic amoxicillin. This process could be important for the development of adverse, and in particular, allergic reactions to this antibiotic. In studies...
LA  - en
PB  - Frontiers
KW  - Amoxicillin
KW  - B-lactam antibiotics
KW  - Inactivation mechanism
KW  - Redox regulation
KW  - Protein adducts
KW  - Thiol groups
KW  - Thiol-containing molecules
KW  - Bacterial growth
KW  - Amoxicilina
KW  - Beta-lactamas
KW  - Crecimiento bacteriano
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Amino Acids, Sulfur::Cysteine::Acetylcysteine
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Penicillins::Penicillin G::Ampicillin::Amoxicillin
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Alcohols::Sugar Alcohols::Dithiothreitol
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Cephalosporins::Cephalexin::Cefaclor
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Specialty Uses of Chemicals::Laboratory Chemicals::Indicators and Reagents::Reducing Agents
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Piperazines::Diketopiperazines
KW  - Medical Subject Headings::Diseases::Immune System Diseases::Hypersensitivity
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Oligopeptides::Glutathione
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Chemical Processes::Physicochemical Processes::Oxidation-Reduction
TI  - Amoxicillin Inactivation by Thiol-Catalyzed Cyclization Reduces Protein Haptenation and Antibacterial Potency
TY  - research article
ER  -