RT Journal Article T1 Impact of Water Exposure and Temperature Changes on Skin Barrier Function. A1 Herrero-Fernandez, Manuel A1 Montero-Vilchez, Trinidad A1 Diaz-Calvillo, Pablo A1 Romera-Vilchez, Maria A1 Buendia-Eisman, Agustin A1 Arias-Santiago, Salvador K1 dermatological diseases K1 homeostasis K1 skin barrier K1 temperature K1 water AB The frequency of hand hygiene has increased due to the COVID-19 pandemic, but there is little evidence regarding the impact of water exposure and temperature on skin. The aim of this study is to evaluate the effect of water exposure and temperature on skin barrier function in healthy individuals. A prospective observational study was conducted. Temperature, pH, transepidermal water loss (TEWL), erythema and stratum corneum hydration (SCH) were measured objectively before and after hot- and cold-water exposure and TempTest® (Microcaya TempTest, Bilbao, Spain) contact. Fifty healthy volunteers were enrolled. Hot-water exposure increased TEWL (25.75 vs. 58.58 g·h-1·m-2), pH (6.33 vs. 6.65) and erythema (249.45 vs. 286.34 AU). Cold-water immersion increased TEWL (25.75 vs. 34.96 g·h-1·m-2) and pH (6.33 vs. 6.62). TEWL (7.99 vs. 9.98 g·h-1·m-2) and erythema (209.07 vs. 227.79 AU) increased after being in contact with the hot region (44 °C) of the TempTest. No significant differences were found after contact with the cold region (4 °C) of the TempTest. In conclusion, long and continuous water exposure damages skin barrier function, with hot water being even more harmful. It would be advisable to use cold or lukewarm water for handwashing and avoid hot water. Knowing the proper temperature for hand washing might be an important measure to prevent flares in patients with previous inflammatory skin diseases on their hands. PB MDPI AG SN 2077-0383 YR 2022 FD 2022-01-03 LK http://hdl.handle.net/10668/21231 UL http://hdl.handle.net/10668/21231 LA en NO Herrero-Fernandez M, Montero-Vilchez T, Diaz-Calvillo P, Romera-Vilchez M, Buendia-Eisman A, Arias-Santiago S. Impact of Water Exposure and Temperature Changes on Skin Barrier Function. J Clin Med. 2022 Jan 7;11(2):298. DS RISalud RD Apr 18, 2025