TY - JOUR AU - EstupiƱan-Moreno, Elkyn AU - Ortiz-Fernandez, Lourdes AU - Li, Tianlu AU - Hernandez-Rodriguez, Jose AU - Ciudad, Laura AU - Andres-Leon, Eduardo AU - Terron-Camero, Laura Carmen AU - Prieto-Gonzalez, Sergio AU - Espigol-Frigole. Georgina AU - Cid, Maria Cinta AU - Marquez, Ana AU - Ballestar, Esteban AU - Martin, Javier PY - 2022 DO - 10.1136/annrheumdis-2022-222156 UR - http://hdl.handle.net/10668/20048 T2 - Annals of the rheumatic diseases AB - Giant cell arteritis (GCA) is a complex systemic vasculitis mediated by the interplay between both genetic and epigenetic factors. Monocytes are crucial players of the inflammation occurring in GCA. Therefore, characterisation of the monocyte... LA - en PB - BMJ Group KW - Giant Cell Arteritis KW - Glucocorticoids KW - Immune Complex Diseases KW - Inflammation KW - Humans KW - DNA Methylation KW - Monocytes KW - Interleukin-11 KW - Glucocorticoids KW - Interleukin-6 KW - integrin alpha7beta1 KW - Epigenome KW - Down-Regulation KW - Transcriptome KW - Inflammation KW - Systemic Vasculitis KW - Phenotype KW - Gene Expression Profiling KW - Epigenesis, Genetic KW - Interleukin-1 TI - Methylome and transcriptome profiling of giant cell arteritis monocytes reveals novel pathways involved in disease pathogenesis and molecular response to glucocorticoids. TY - research article VL - 81 ER -