TY  - JOUR
AU  - Fernandez-Valenzuela, Juan Jose
AU  - Sanchez-Varo, Raquel
AU  - Muñoz-Castro, Clara
AU  - De Castro, Vanessa
AU  - Sanchez-Mejias, Elisabeth
AU  - Navarro, Victoria
AU  - Jimenez, Sebastian
AU  - Nuñez-Diaz, Cristina
AU  - Gomez-Arboledas, Angela
AU  - Moreno-Gonzalez, Ines
AU  - Vizuete, Marisa
AU  - Davila, Jose Carlos
AU  - Vitorica, Javier
AU  - Gutierrez, Antonia
PY  - 2020
DO  - 10.1038/s41598-020-71767-4
UR  - http://hdl.handle.net/10668/3590
T2  - Scientific Reports
AB  - In Alzheimer's disease (AD), and other tauopathies, microtubule destabilization compromises axonal and synaptic integrity contributing to neurodegeneration. These diseases are characterized by the intracellular accumulation of hyperphosphorylated tau...
LA  - en
PB  - Springer Nature
KW  - Amyloid
KW  - Alzheimer disease
KW  - Axonal transport
KW  - Brain
KW  - Interneurons
KW  - Tauopathies
KW  - Amiloide
KW  - Enfermedad de Alzheimer
KW  - Transporte axonal
KW  - Encéfalo
KW  - Interneuronas
KW  - Tauopatías
KW  - Medical Subject Headings::Diseases::Nervous System Diseases::Neurodegenerative Diseases::Tauopathies::Alzheimer Disease
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cytoplasmic Streaming::Axonal Transport
KW  - Medical Subject Headings::Psychiatry and Psychology::Mental Disorders::Delirium, Dementia, Amnestic, Cognitive Disorders::Cognition Disorders
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Lactones::Macrolides::Epothilones
KW  - Medical Subject Headings::Check Tags::Female
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Check Tags::Male
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Genetically Modified::Mice, Transgenic
KW  - Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Cytoskeleton::Microtubules
KW  - Medical Subject Headings::Anatomy::Nervous System::Neurons
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype
KW  - Medical Subject Headings::Diseases::Nervous System Diseases::Neurodegenerative Diseases::Tauopathies
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Mitosis Modulators::Antimitotic Agents::Tubulin Modulators
KW  - Medical Subject Headings::Diseases::Animal Diseases::Disease Models, Animal
TI  - Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer's disease model
TY  - research article
ER  -