RT Journal Article
T1 TET2, an "ambiguous" player in inflammation.
A1 Espinosa-Oliva, Ana Maria
A1 Burguillos, Miguel Angel
K1 Microglia
K1 Central nervous system
K1 Innate immune response
K1 Neuroinflammation
K1 Parkinson disease
K1 Alzheimer disease
AB Microglial cells, the “macrophages” from the central nervous system (CNS), perform a variety of roles necessary to keep the homeostasis in the healthy brain. However, microglial cells are best known for their role as “ first responders” through initiation of an innate immune response against a wide variety of deleterious stimuli in the brain. This controlled inflammatory response is beneficial and disappears once the deleterious stimuli are gone. But, it is also well-acknowledged that uncontrolled activation may transform into a chronic neuroinflammatory response which is partially responsible for the progression of the disease, for instance in Parkinson’s disease (PD) and Alzheimer’s disease (AD) (Shen et al., 2018). For this reason, microglia have become a target in the search for new therapeutic strategies to hinder the progression of different neurodegenerative diseases, such as PD or AD.
PB Cell Press
SN 1673-5374
YR 2020
FD 2020-08
LK http://hdl.handle.net/10668/15021
UL http://hdl.handle.net/10668/15021
LA en
NO Espinosa-Oliva AM, Burguillos MA. TET2, an "ambiguous" player in inflammation. Neural Regen Res. 2020 Aug;15(8):1481-1482.
DS RISalud
RD Sep 18, 2025