RT Journal Article
T1 Effect of a specific supplement enriched with n-3 polyunsaturated fatty acids on markers of inflammation, oxidative stress and metabolic status of ear, nose and throat cancer patients.
A1 Roca-Rodríguez, M M
A1 García-Almeida, J M
A1 Lupiáñez-Pérez, Y
A1 Rico, J M
A1 Toledo, M
A1 Alcaide-Torres, J
A1 Cardona, F
A1 Medina, J A
A1 Tinahones, F J
K1 Metabolic status
K1 Radiotherapy
K1 IL6 protein, human
K1 Interleukin-6
K1 Hydrogen Peroxide
K1 n-3 polyunsaturated fatty acids
K1 Oxidative stress
K1 Inflammaation
K1 Metabolic status
K1 Suplementos dietéticos
K1 Neoplasias del oído
K1 Electrólitos
K1 Ácidos grasos insaturados
K1 Glutatión peroxidasa
K1 Peróxido de hidrógeno
K1 Inflamación
K1 Interleucina-6
K1 Desnutrición
K1 Neoplasias nasale
K1 Estrés oxidativo
K1 Neoplasias Faríngeas
K1 Antioxidantes
K1 Índice de masa corporal
K1 Proteína C-reactiva
K1 Fibras en la dieta
AB Malnutrition affects 40-50% of patients with ear, nose and throat (ENT) cancer. The aim of this study was to assess changes induced by a specific nutritional supplement enriched with n-3 polyunsaturated fatty acids, fiber and greater amounts of proteins and electrolytes, as compared with a standard nutritional supplement, on markers of inflammation, oxidative stress and metabolic status of ENT cancer patients undergoing radiotherapy (RT). Fourteen days after starting RT, 26 patients were randomly allocated to one of two groups, 13 supplemented with Prosure, an oncologic formula enriched with n-3 polyunsaturated fatty acids, fiber and greater amounts of proteins and electrolytes (specific supplement), and 13 supplemented with Standard-Isosource (standard supplement). Patients were evaluated before RT, and 14, 28 and 90 days after starting RT. The results showed that there were no significant differences between the groups, but greater changes were observed in the standard supplement group, such as a decline in body mass index (BMI), reductions in hematocrit, erythrocyte, eosinophil and albumin levels, and a rise in creatinine and urea levels. We concluded that metabolic, inflammatory and oxidative stress parameters were altered during RT, and began to normalize at the end of the study. Patients supplemented with Prosure showed an earlier normalization of these parameters, with more favorable changes in oxidative stress markers and a more balanced evolution, although the difference was not significant.
PB Spandidos Publications
SN 1021-335X
YR 2014
FD 2014-01
LK http://hdl.handle.net/10668/1853
UL http://hdl.handle.net/10668/1853
LA en
NO Roca-Rodríguez MM, García-Almeida JM, Lupiáñez-Pérez Y, Rico JM, Toledo M, Alcaide-Torres J, et al. Effect of a specific supplement enriched with n-3 polyunsaturated fatty acids on markers of inflammation, oxidative stress and metabolic status of ear, nose and throat cancer patients. Oncol. Rep.. 2014; 31(1):405-14
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 11, 2025