RT Journal Article
T1 EHO-85: A Multifunctional Amorphous Hydrogel for Wound Healing Containing Olea europaea Leaf Extract: Effects on Wound Microenvironment and Preclinical Evaluation.
A1 Casado-Diaz, Antonio
A1 La Torre, Manuel
A1 Priego-Capote, Feliciano
A1 Verdu-Soriano, Jose
A1 Lazaro-Martinez, Jose Luis
A1 Rodriguez-Mañas, Leocadio
A1 Berenguer Perez, Miriam
A1 Tunez, Isaac
K1 EHO-85
K1 Olea europaea leaf extract
K1 ROS
K1 Antioxidant
K1 Hydrogel
K1 Moistening
K1 pH
K1 Preclinical
K1 Wound healing
AB The prevalence of chronic wounds is increasing due to the population aging and associated pathologies, such as diabetes. These ulcers have an important socio-economic impact. Thus, it is necessary to design new products for their treatment with an adequate cost/effectiveness ratio. Among these products are amorphous hydrogels. Their composition can be manipulated to provide a favorable environment for ulcer healing. The aim of this study was to evaluate a novel multifunctional amorphous hydrogel (EHO-85), containing Olea europaea leaf extract, designed to enhance the wound healing process. For this purpose, its moistening ability, antioxidant capacity, effect on pH in the wound bed of experimental rats, and the effect on wound healing in a murine model of impaired wound healing were assessed. EHO-85 proved to be a remarkable moisturizer and its application in a rat skin wound model showed a significant antioxidant effect, decreasing lipid peroxidation in the wound bed. EHO-85 also decreased the pH of the ulcer bed from day 1. In addition, in mice (BKS. Cg-m +/+ Leprdb) EHO-85 treatment showed superior wound healing rates compared to hydrocolloid dressing. In conclusion, EHO-85 can speed up the closure of hard-to-heal wounds due to its multifunctional properties that are able to modulate the wound microenvironment, mainly through its remarkable effect on reactive oxygen species, pH, and moistening regulation.
PB MDPI
SN 2077-0383
YR 2022
FD 2022-02-22
LK http://hdl.handle.net/10668/21246
UL http://hdl.handle.net/10668/21246
LA en
NO Casado-Díaz A, La Torre M, Priego-Capote F, Verdú-Soriano J, Lázaro-Martínez JL, Rodríguez-Mañas L, et al. EHO-85: A Multifunctional Amorphous Hydrogel for Wound Healing Containing Olea europaea Leaf Extract: Effects on Wound Microenvironment and Preclinical Evaluation. J Clin Med. 2022 Feb 24;11(5):1229
DS RISalud
RD Apr 20, 2025