RT Journal Article
T1 A Narrative Review about Autism Spectrum Disorders and Exclusion of Gluten and Casein from the Diet.
A1 González-Domenech, Pablo José
A1 Diaz-Atienza, Francisco
A1 Gutiérrez-Rojas, Luis
A1 Fernández-Soto, María Luisa
A1 González-Domenech, Carmen María
K1 autism spectrum disorders
K1 casein
K1 diet
K1 gluten
AB Autism spectrum disorders (ASDs) appear in the early stages of neurodevelopment, and they remain constant throughout life. Currently, due to limitations in ASDs treatment, alternative approaches, such as nutritional interventions, have frequently been implemented. The aim of this narrative review is to gather the most relevant and updated studies about dietary interventions related to ASDs etiopathogenesis. Our literature search focused on the gluten- and casein-free (GFCF) diet. The literature found shows the inexistence of enough scientific evidence to support a general recommendation of dietary intervention in children with ASD. Protocols and procedures for assessing risk and safety are also needed. Future lines: Prospective and controlled research studies with larger sample sizes and longer follow-up times are scarce and needed. In addition, studies considering an assessment of intestinal permeability, bacterial population, enzymatic, and inflammatory gastrointestinal activity are interesting to identify possible responders. Besides brain imaging techniques, genetic tests can also contribute as markers to evaluate the comorbidity of gastrointestinal symptoms.
YR 2022
FD 2022-04-25
LK http://hdl.handle.net/10668/21472
UL http://hdl.handle.net/10668/21472
LA en
DS RISalud
RD Apr 9, 2025