RT Journal Article
T1 Bosentan and oral anticoagulants in HIV patients: what we can learn of cases reported so far.
A1 Morales-Molina, José Antonio
A1 Martínez-de la Plata, Juan Enrique
A1 Urquízar-Rodríguez, Olivia
A1 Molina-Arrebola, María Angustias
K1 Drug Interactions
K1 Interacciones de Drogas
K1 HIV Patients
K1 VIH
K1 Acenocoumarol
K1 Acenocumarol
K1 Bosentan
K1 Warfarin
K1 Warfarina
K1 Hipertensión Pulmonar
AB Pulmonary arterial hypertension is an infrequent but nevertheless serious life-threatening severe complication of HIV infection. It can be treated with bosentan and oral anticoagulants. Bosentan could induce the acenocoumarol metabolism and it increases the INR values. Until now, no study of interaction between bosentan and oral anticoagulants in HIV patients has reported. So we present a case of this interaction between these drugs and we reviewed MEDLINE to identify all the papers published so far. In our case, several weeks after increasing dose of bosentan acenocoumarol dose had to be progressively increased to 70 mg/week (+33%) without obtaining an adequate INR level (2.0-3.0). Forty-nine days later, we achieved a therapeutic INR with 90 mg/week of warfarin. The use of bosentan and oral anticoagulants together in these patients require a closer monitoring during first weeks of treatment, after increasing the bosentan dose and even during longer periods of time.
PB PAGEPress Publications
SN 2038-8322
YR 2011
FD 2011-09-16
LK http://hdl.handle.net/10668/699
UL http://hdl.handle.net/10668/699
LA en
NO Morales-Molina JA, Martínez-de la Plata JE, Urquízar-Rodríguez O, Molina-Arrebola MA. Bosentan and oral anticoagulants in HIV patients: what we can learn of cases reported so far. Hematol Rep. 2011 Aug; 3(2):e16
NO Journal Article;
DS RISalud
RD Apr 8, 2025