RT Journal Article
T1 Risk Model for Prostate Cancer Using Environmental and Genetic Factors in the Spanish Multi-Case-Control (MCC) Study.
A1 Gómez-Acebo, Inés
A1 Dierssen-Sotos, Trinidad
A1 Fernandez-Navarro, Pablo
A1 Palazuelos, Camilo
A1 Moreno, Víctor
A1 Aragonés, Nuria
A1 Castaño-Vinyals, Gemma
A1 Jiménez-Monleón, Jose J
A1 Ruiz-Cerdá, Jose Luis
A1 Pérez-Gómez, Beatriz
A1 Ruiz-Dominguez, José Manuel
A1 Molero, Jessica Alonso
A1 Pollán, Marina
A1 Kogevinas, Manolis
A1 Llorca, Javier
AB Prostate cancer (PCa) is the second most common cancer among men worldwide. Its etiology remains largely unknown compared to other common cancers. We have developed a risk stratification model combining environmental factors with family history and genetic susceptibility. 818 PCa cases and 1,006 healthy controls were compared. Subjects were interviewed on major lifestyle factors and family history. Fifty-six PCa susceptibility SNPs were genotyped. Risk models based on logistic regression were developed to combine environmental factors, family history and a genetic risk score. In the whole model, compared with subjects with low risk (reference category, decile 1), those carrying an intermediate risk (decile 5) had a 265% increase in PCa risk (OR = 3.65, 95% CI 2.26 to 5.91). The genetic risk score had an area under the ROC curve (AUROC) of 0.66 (95% CI 0.63 to 0.68). When adding the environmental score and family history to the genetic risk score, the AUROC increased by 0.05, reaching 0.71 (95% CI 0.69 to 0.74). Genetic susceptibility has a stronger risk value of the prediction that modifiable risk factors. While the added value of each SNP is small, the combination of 56 SNPs adds to the predictive ability of the risk model.
YR 2017
FD 2017-08-21
LK http://hdl.handle.net/10668/11526
UL http://hdl.handle.net/10668/11526
LA en
DS RISalud
RD Apr 6, 2025