TY  - JOUR
AU  - García-Godoy, María Jesús
AU  - López-Camacho, Esteban
AU  - García-Nieto, José
AU  - Nebro, Antonio J
AU  - Aldana-Montes, José F
PY  - 2016
DO  - 10.3390/molecules21111575
UR  - https://hdl.handle.net/10668/24604
T2  - Molecules (Basel, Switzerland)
AB  - The human Epidermal Growth Factor (EGFR) plays an important role in signaling pathways, such as cell proliferation and migration. Mutations like G719S, L858R, T790M, G719S/T790M or T790M/L858R can alter its conformation, and, therefore, drug responses...
LA  - en
KW  - Epidermal Growth Factor Receptor
KW  - Epidermal Growth Factor Receptor mutants
KW  - drug resistance
KW  - epidermal growth factor
KW  - metaheuristics
KW  - molecular docking
KW  - multi-objective optimization
KW  - Algorithms
KW  - Binding Sites
KW  - Drug Resistance, Multiple
KW  - Drug Resistance, Neoplasm
KW  - ErbB Receptors
KW  - Humans
KW  - Ligands
KW  - Molecular Conformation
KW  - Molecular Docking Simulation
KW  - Molecular Dynamics Simulation
KW  - Protein Binding
KW  - Protein Kinase Inhibitors
KW  - Quantitative Structure-Activity Relationship
TI  - Molecular Docking Optimization in the Context of Multi-Drug Resistant and Sensitive EGFR Mutants.
TY  - research article
VL  - 21
ER  -