%0 Journal Article
%A Corral, Jaime
%A Mogollon, Maria Victoria
%A Sánchez-Quiroga, M-Ángeles
%A Gómez de Terreros, Javier
%A Romero, Auxiliadora
%A Caballero, Candela
%A Teran-Santos, Joaquin
%A Alonso-Álvarez, María L
%A Gómez-García, Teresa
%A González, Mónica
%A López-Martínez, Soledad
%A de Lucas, Pilar
%A Marin, José M
%A Romero, Odile
%A Díaz-Cambriles, Trinidad
%A Chiner, Eusebi
%A Egea, Carlos
%A Lang, Roberto M
%A Mokhlesi, Babak
%A Masa, Juan F
%A Spanish Sleep Network
%T Echocardiographic changes with non-invasive ventilation and CPAP in obesity hypoventilation syndrome.
%D 2017
%U http://hdl.handle.net/10668/11809
%X Despite a significant association between obesity hypoventilation syndrome (OHS) and cardiac dysfunction, no randomised trials have assessed the impact of non-invasive ventilation (NIV) or CPAP on cardiac structure and function assessed by echocardiography. We performed a secondary analysis of the data from the largest multicentre randomised controlled trial of OHS (Pickwick project, n=221) to determine the comparative efficacy of 2 months of NIV (n=71), CPAP (n=80) and lifestyle modification (control group, n=70) on structural and functional echocardiographic changes. Conventional transthoracic two-dimensional and Doppler echocardiograms were obtained at baseline and after 2 months. Echocardiographers at each site were blinded to the treatment arms. Statistical analysis was performed using intention-to-treat analysis. At baseline, 55% of patients had pulmonary hypertension and 51% had evidence of left ventricular hypertrophy. Treatment with NIV, but not CPAP, lowered systolic pulmonary artery pressure (-3.4 mm Hg, 95% CI -5.3 to -1.5; adjusted P=0.025 vs control and P=0.033 vs CPAP). The degree of improvement in systolic pulmonary artery pressure was greater in patients treated with NIV who had pulmonary hypertension at baseline (-6.4 mm Hg, 95% CI -9 to -3.8). Only NIV therapy decreased left ventricular hypertrophy with a significant reduction in left ventricular mass index (-5.7 g/m2; 95% CI -11.0 to -4.4). After adjusted analysis, NIV was superior to control group in improving left ventricular mass index (P=0.015). Only treatment with NIV led to a significant improvement in 6 min walk distance (32 m; 95% CI 19 to 46). In patients with OHS, medium-term treatment with NIV is more effective than CPAP and lifestyle modification in improving pulmonary hypertension, left ventricular hypertrophy and functional outcomes. Long-term studies are needed to confirm these results. Pre-results, NCT01405976 (https://clinicaltrials.gov/).
%K non invasive ventilation
%K sleep apnoea
%~