RT Journal Article
T1 Anatomical and clinical predictors of valve dysfunction and aortic dilation in bicuspid aortic valve disease.
A1 Evangelista, Arturo
A1 Gallego, Pastora
A1 Calvo-Iglesias, Francisco
A1 Bermejo, Javier
A1 Robledo-Carmona, Juan
A1 Sánchez, Violeta
A1 Saura, Daniel
A1 Arnold, Roman
A1 Carro, Amelia
A1 Maldonado, Giuliana
A1 Sao-Avilés, Augusto
A1 Teixidó, Gisela
A1 Galian, Laura
A1 Rodríguez-Palomares, José
A1 García-Dorado, David
K1 aortic dilation
K1 aortic regurgitation
K1 aortic stenosis
K1 bicuspid aortic valve
K1 echocardiography
K1 valvular heart disease
AB Bicuspid aortic valve (BAV) is associated with early valvular dysfunction and proximal aorta dilation with high heterogeneity. This study aimed to assess the determinants of these complications. Eight hundred and fifty-two consecutive adults diagnosed of BAV referred from cardiac outpatient clinics to eight echocardiographic laboratories of tertiary hospitals were prospectively recruited. Exclusion criteria were aortic coarctation, other congenital disorders or intervention. BAV morphotype, significant valve dysfunction and aorta dilation (≥2 Z-score) at sinuses and ascending aorta were established. Three BAV morphotypes were identified: right-left coronary cusp fusion (RL) in 72.9%, right-non-coronary (RN) in 24.1% and left-non-coronary (LN) in 3.0%. BAV without raphe was observed in 18.3%. Multivariate analysis showed aortic regurgitation (23%) to be related to male sex (OR: 2.80, p Normofunctional valves are more prevalent in BAV without raphe. Aortic stenosis is more frequent in BAV-RN and associated with some cardiovascular risk factors, whereas aortic regurgitation (AR) is associated with male sex and sigmoid prolapse. Although ascending aorta is the most commonly dilated segment, aortic root dilation is present in one-third of patients and associated with AR. Remarkably, BAV-RL increases the risk for dilation of the proximal aorta, whereas BAV-RN spares this area.
YR 2017
FD 2017-09-01
LK http://hdl.handle.net/10668/11552
UL http://hdl.handle.net/10668/11552
LA en
DS RISalud
RD Apr 6, 2025