RT Journal Article
T1 Opioids and Ocular Surface Pathology: A Literature Review of New Treatments Horizons.
A1 Garcia-Lopez, Celia
A1 Gomez-Huertas, Carmen
A1 Sanchez-Gonzalez, Jose-Maria
A1 Borroni, Davide
A1 Rodriguez-Calvo-de-Mora, Marina
A1 Romano, Vito
A1 Rachwani-Anil, Rahul
A1 Ramos-Lopez, Juan-Francisco
A1 Ortiz-Perez, Santiago
A1 Rocha-de-Lossada, Carlos
K1 Cornea
K1 Neuropathic corneal pain
K1 Ocular surface
K1 Opioids
K1 Wound healing
K1 Área de Gestión Sanitaria Norte de Málaga
AB This review discusses the role of opioids in the corneal surface and the different pathways and therapeutic methods of management. A literature review was performed using PubMed database. For the database search, the main searching words "opioid" and "topical opioid treatment" were used with the descriptors "cornea", "ocular surface", "neuropathic corneal pain", "corneal sensitivity" and "naltrexone"; original scientific articles and reviews were included to achieve the purpose of the review. The endogenous opioid system has relevant functions in the organism, and in daily use, opioids are used as painkillers. However, these drugs may be employed for other indications as opioid pathways have a wide spectrum. The corneal surface for topical treatment is easily accessible, hence sparing the side effects of systemic opioids. Instillation of opioid antagonist substances, such as naltrexone, increases corneal healing rates and stimulates the division of corneal epithelium cells without deleterious effects. The natural modulation of endogenous opioids controls different forms of pain, including inflammatory and neuropathic pain, both in the ocular surface and in the central nervous system. There are diverse methods in controlling pain using opioids, especially in refractory forms. This review attempts to collect the literature about corneal surface and opioid pathways to provide an overview image and a possible direction of the news treatments.
PB MDPI
SN 2077-0383
YR 2022
FD 2022-03-04
LK http://hdl.handle.net/10668/21251
UL http://hdl.handle.net/10668/21251
LA en
NO García-López C, Gómez-Huertas C, Sánchez-González JM, Borroni D, Rodríguez-Calvo-de-Mora M, Romano V, et al. Opioids and Ocular Surface Pathology: A Literature Review of New Treatments Horizons. J Clin Med. 2022 Mar 4;11(5):1424
DS RISalud
RD Apr 17, 2025