RT Journal Article
T1 Serum from postmenopausal women treated with a by-product of olive-oil extraction process stimulates osteoblastogenesis and inhibits adipogenesis in human mesenchymal stem-cells (MSC).
A1 Casado-Diaz, Antonio
A1 Tunez-Fiñana, Isaac
A1 Mata-Granados, Jose Maria
A1 Ruiz-Mendez, Maria Victoria
A1 Dorado, Gabriel
A1 Romero-Sanchez, Maria Concepcion
A1 Navarro-Valverde, Cristina
A1 Quesada-Gomez, Jose Manuel
K1 Adipocytes
K1 Aging
K1 Mesenchymal stem-cells
K1 Olive-pomace oil distillate
K1 Osteoblasts
K1 Osteoporosis
K1 AGS - Sur de Sevilla
AB Aging may enhance both oxidative stress and bone-marrow mesenchymal stem-cell (MSC) differentiation into adipocytes. That reduces osteoblastogenesis, thus favoring bone-mass loss and fracture, representing an important worldwide health-issue, mainly in countries with aging populations. Intake of antioxidant products may help to retain bone-mass density. Interestingly, a novel olive-pomace physical treatment to generate olive oil also yields by-products rich in functional antioxidants. Thus, diet of postmenopausal women was supplemented for two months with one of such by-products (distillate 6; D6), being rich in squalene. After treatment, serum from such women showed reduced both lipidic peroxidation and oxidized low-density lipoprotein (LDL). Besides, vitamin E and coenzyme Q10 levels increased. Furthermore, culture medium containing 10% of such serum both increased osteoblastogenesis and reduced adipogenesis in human MSC from bone marrow. Therefore, highly antioxidant by-products like D6 may represent a relevant source for development of functional products, for both prevention and treatment of degenerative pathologies associated with aging, like osteoporosis.
PB Elsevier
YR 2017
FD 2017-01-26
LK http://hdl.handle.net/10668/10848
UL http://hdl.handle.net/10668/10848
LA en
NO Casado-Díaz A, Túnez-Fiñana I, Mata-Granados JM, Ruiz-Méndez MV, Dorado G, Romero-Sánchez MC, et al. Serum from postmenopausal women treated with a by-product of olive-oil extraction process stimulates osteoblastogenesis and inhibits adipogenesis in human mesenchymal stem-cells (MSC). Exp Gerontol. 2017 Apr;90:71-78
DS RISalud
RD Apr 10, 2025