%0 Journal Article
%A Casado-Diaz, Antonio
%A Tunez-Fiñana, Isaac
%A Mata-Granados, Jose Maria
%A Ruiz-Mendez, Maria Victoria
%A Dorado, Gabriel
%A Romero-Sanchez, Maria Concepcion
%A Navarro-Valverde, Cristina
%A Quesada-Gomez, Jose Manuel
%T Serum from postmenopausal women treated with a by-product of olive-oil extraction process stimulates osteoblastogenesis and inhibits adipogenesis in human mesenchymal stem-cells (MSC).
%D 2017
%U http://hdl.handle.net/10668/10848
%X Aging may enhance both oxidative stress and bone-marrow mesenchymal stem-cell (MSC) differentiation into adipocytes. That reduces osteoblastogenesis, thus favoring bone-mass loss and fracture, representing an important worldwide health-issue, mainly in countries with aging populations. Intake of antioxidant products may help to retain bone-mass density. Interestingly, a novel olive-pomace physical treatment to generate olive oil also yields by-products rich in functional antioxidants. Thus, diet of postmenopausal women was supplemented for two months with one of such by-products (distillate 6; D6), being rich in squalene. After treatment, serum from such women showed reduced both lipidic peroxidation and oxidized low-density lipoprotein (LDL). Besides, vitamin E and coenzyme Q10 levels increased. Furthermore, culture medium containing 10% of such serum both increased osteoblastogenesis and reduced adipogenesis in human MSC from bone marrow. Therefore, highly antioxidant by-products like D6 may represent a relevant source for development of functional products, for both prevention and treatment of degenerative pathologies associated with aging, like osteoporosis.
%K Adipocytes
%K Aging
%K Mesenchymal stem-cells
%K Olive-pomace oil distillate
%K Osteoblasts
%K Osteoporosis
%K AGS - Sur de Sevilla
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