TY  - JOUR
AU  - Matas-Rico, Elisa
AU  - Frijlink, Elselien
AU  - van der Haar Àvila, Irene
AU  - Menegakis, Apostolos
AU  - van Zon, Maaike
AU  - Morris, Andrew J.
AU  - Koster, Jan
AU  - Salgado-Polo, Fernando
AU  - de Kivit, Sander
AU  - Lança, Telma
AU  - Mazzocca, Antonio
AU  - Johnson, Zoë
AU  - Haanen, John
AU  - Schumacher, Ton N.
AU  - Perrakis, Anastassis
AU  - Verbrugge, Inge
AU  - van den Berg, Joost H.
AU  - Borst, Jannie
AU  - Moolenaar, Wouter H.
PY  - 2021
DO  - 10.1016/j.celrep.2021.110013
UR  - http://hdl.handle.net/10668/3753
T2  - Cell Reports
AB  - Autotaxin (ATX; ENPP2) produces lysophosphatidic acid (LPA) that regulates multiple biological functions via cognate G protein-coupled receptors LPAR1-6. ATX/LPA promotes tumor cell migration and metastasis via LPAR1 and T cell motility via LPAR2, yet...
LA  - en
PB  - Cell Press
KW  - G protein-coupled receptors
KW  - T cells
KW  - Anti-cancer vaccination
KW  - Autotaxin
KW  - Chemorepulsion
KW  - Immunotherapy
KW  - Iysophosphatidic acid
KW  - Melanoma
KW  - Single-cell RNAseq
KW  - Tumor microenvironment
KW  - Receptores acoplados a proteínas G
KW  - Linfocitos T
KW  - Inmunoterapia
KW  - Microambiente tumoral
KW  - Neoplasias
KW  - Células
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes::CD8-Positive T-Lymphocytes
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Movement::Chemotaxis
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy::Immunization::Immunotherapy, Active::Vaccination
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::Lymphocytes, Tumor-Infiltrating
KW  - Medical Subject Headings::Chemicals and Drugs::Lipids::Membrane Lipids::Phospholipids::Glycerophosphates::Phosphatidic Acids::Lysophospholipids
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice::Mice, Inbred Strains::Mice, Inbred C57BL
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Phosphoric Diester Hydrolases
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, G-Protein-Coupled::Receptors, Lysophospholipid::Receptors, Lysophosphatidic Acid
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment
TI  - Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells
TY  - research article
ER  -