RT Conference Proceedings
T1 ASSOCIATION BETWEEN DIFFERENT HLADRB1 ALLELES AND SEVERITY IN RHEUMATOID ARTHRITIS
A1 Rojas-Gimenez, M.
A1 Gutierrez, J. Calvo
A1 Lopez-Medina, C.
A1 Castro, R. Ortega
A1 Ladehesa Pineda, M. L.
A1 Contreras, A. Escudero
AB Objectives: To evaluate the association between different HLADRB1 alleles and the development of serious complications in patients with rheumatoid arthritis (RA). Methods: We performed an observational, longitudinal and retrospective study of a cohort of 134 patients with established RA (ACR/EULAR 2010) from the registry of our department, older than 18 years and without other associated autoimmune pathologies except secondary Sjogren’s syndrome and who had the requested HLADRB1 genotype. Patients with ≥ 1 of the following HLA-DRB1 alleles were considered positive shared epitope carriers (SE+): *01:01, *01:02, *04:01, *04:04, *04:05, * 10:01, *03:01 or *07:01. The remaining patients without any of these alleles were considered shared epitope negative (SE-). Serious complications of RA were included: interstitial lung disease, cardiovascular events, cancer, admissions for serious infections, vasculitis, Felty’s syndrome, or death. Other severity data: erosions, rheumatoid nodules, multiple resistance to biologicals (3 or more biologicals), secondary Sjogren’s syndrome or osteoporosis. Descriptive and bivariate analysis was performed between the differentalleles (χ2 /ANOVA). Cox regression analysis was performed to estimate the influence of the different alleles on mortality.
PB Bmj publishing group
SN 0003-4967
YR 2022
FD 2022-06-01
LK http://hdl.handle.net/10668/20076
UL http://hdl.handle.net/10668/20076
LA en
NO Rojas-Giménez M, Gutierrez JC, López-Medina C, Castro RO, Pineda MLL, Contreras AE. AB0264 ASSOCIATION BETWEEN DIFFERENT HLADRB1 ALLELES AND SEVERITY IN RHEUMATOID ARTHRITIS. Annals Of The Rheumatic Diseases [Internet]. 23 de mayo de 2022;81(Suppl 1):1258.2-1259. Disponible en: https://doi.org/10.1136/annrheumdis-2022-eular.1844
DS RISalud
RD Apr 10, 2025