%0 Journal Article
%A Barrios, R Haridian Sosa
%A Burguera Vion, Víctor
%A Álvarez Nadal, Marta
%A Cintra Cabrera, Melissa
%A Elías Triviño, Sandra
%A Villa Hurtado, Daniel
%A Ortego, Sofía
%A Fernández Lucas, Milagros
%A Rivera-Gorrin, Maite
%T Safety of renal biopsy bleeding prophylaxis with desmopressin.
%D 2021
%U https://hdl.handle.net/10668/27589
%X Percutaneous renal biopsy (PRB) is invasive, and bleeding-related complications are a concern. Desmopressin (DDAVP) is a selective type 2 vasopressin receptor-agonist also used for haemostasis. To evaluate the side effects of intravenous (IV) weight-adjusted desmopressin preceding PRB. This was a retrospective study of renal biopsies performed by nephrologists from 2013 to 2017 in patients who received single-dose DDAVP pre-PRB. Of 482 PRBs, 65 (13.5%) received DDAVP (0.3 µg/kg); 55.4% of the PRBs were native kidneys. Desmopressin indications were altered platelet function analyser (PFA)-100 results (75.3% of the patients), urea >24.9 mmol/L (15.5%), antiplatelet drugs (6.1%) and thrombocytopaenia (3%). Of the 65 patients, 30.7% had minor asymptomatic complications, and 3 patients had major complications. Pre-PRB haemoglobin (Hb) 24.9 mmol/L (15.5%), antiplatelet drugs (6.1%) and thrombocytopaenia (3%). Of the 65 patients, 30.7% had minor asymptomatic complications, and 3 patients had major complications. Pre-PRB haemoglobin (Hb) 10 g/L, and altered collagen-epinephrine (Col-Epi) time was a significant risk factor for overall complications. Mean sodium decrease was 0.6 ± 3 mmol/L. Hyponatraemia without neurological symptoms was diagnosed in two patients; no cardiovascular events occurred. Hyponatraemia after single-dose DDAVP is rare. A single IV dose of desmopressin adjusted to the patient's weight is safe as pre-PRB bleeding prophylaxis.
%K 1-deamino8-D-arginine vasopressin
%K Renal biopsy
%K bleeding
%K cardiovascular event
%K desmopressin safety
%K hyponatraemia
%K interventional nephrology
%K prophylaxis
%K secondary effect
%K uraemia
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