RT Journal Article T1 [Interventions for improving adherence to treatment in patients with multiple pathologies: overview of systematic reviews]. T2 Intervenciones para la mejora de la adherencia al tratamiento en pacientes pluripatológicos: resumen de revisiones sistemáticas. A1 González-Bueno, Javier A1 Vega-Coca, María Dolores A1 Rodríguez-Pérez, Aitana A1 Toscano-Guzmán, María Dolores A1 Pérez-Guerrero, Concepción A1 Santos-Ramos, Bernardo K1 Adherence, Interventions K1 Adherencia K1 Chronic K1 Crónico K1 Intervenciones K1 Paciente pluripatológico K1 Patient with multiple chronic conditions K1 Revisión sistemática K1 Systematic reviews AB To assess the available scientific evidence regarding the efficacy of interventions aimed to enhance medication adherence in patients with multiple chronic conditions (PMCC). Overview of systematic reviews. The following databases were consulted (September 2013): Pubmed, EMBASE, the Cochrane Library, CRD and WoS to identify interventions aimed to enhance medication adherence in PMCC, or otherwise, patients with chronic diseases common in the PMCC, or polypharmacy. Systematic reviews of clinical trials focused on PMCC or similar were included. They should compare the efficacy of any intervention aimed to improve compliance to prescribed and self-administered medications with clinical practice or other interventions. Information about the study population, nature of intervention and efficacy in terms of improved adherence was extracted. 566 articles were retrieved of which 9 systematic reviews were included. None was specifically focused on PMCC but considered patients with chronic diseases common in the PMCC, patients with more than one chronic disease and polypharmacy. The overall effectiveness of interventions was modest without relevant differences between behavioural, educational and combined interventions. Some components of these interventions including patient counselling and regimen simplification appear to be effective tools in improving adherence in this population group. There is a large heterogeneity of interventions aimed to improve adherence with modest efficacy, none in PMCC. YR 2015 FD 2015-06-09 LK http://hdl.handle.net/10668/9894 UL http://hdl.handle.net/10668/9894 LA es DS RISalud RD Apr 5, 2025