RT Journal Article
T1 Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study.
A1 Rueda-Gotor, Javier
A1 Lopez-Mejias, Raquel
A1 Remuzgo-Martinez, Sara
A1 Pulito-Cueto, Veronica
A1 Corrales, Alfonso
A1 Lera-Gomez, Leticia
A1 Portilla, Virginia
A1 Gonzalez-Mazon, Iñigo
A1 Blanco, Ricardo
A1 Exposito, Rosa
A1 Mata, Cristina
A1 Llorca, Javier
A1 Hernandez-Hernandez, Vanesa
A1 Rodriguez-Lozano, Carlos
A1 Barbarroja, Nuria
A1 Castro, Rafaela Ortega
A1 Vicente, Esther
A1 Fernandez-Carballido, Cristina
A1 Martinez-Vidal, Maria Paz
A1 Castro-Corredor, David
A1 Anino-Fernandez, Joaquin
A1 Peiteado, Diana
A1 Plasencia-Rodriguez, Chamaida
A1 Galindez-Agirregoikoa, Eva
A1 García-Vivar, María Luz
A1 Gualillo, Oreste
A1 Quevedo-Abeledo, Juan Carlos
A1 Castañeda, Santos
A1 Ferraz-Amaro, Ivan
A1 Gonzalez-Gay, Miguel A
A1 Genre, Fernanda
K1 Axial spondyloarthritis
K1 Biomarker
K1 Cardiovascular risk
K1 Polymorphism
K1 Subclinical atherosclerosis
K1 Vaspin
AB Vaspin is a novel anti-inflammatory adipokine associated with cardiovascular (CV) disease and inflammation in chronic inflammatory conditions different from axial spondyloarthritis (axSpA). Given the high incidence of CV disease (mainly due to accelerated atherosclerosis) exhibited by axSpA patients, we wondered if vaspin could also be a key molecule in this process. However, data on the role of vaspin regarding atherosclerotic disease in the context of axSpA is scarce. For this reason, we aimed to evaluate the implication of vaspin, at the genetic and serological level, in subclinical atherosclerosis and CV risk in axSpA. This study included 510 patients diagnosed with axSpA. Carotid ultrasound (US) was performed to evaluate the presence of subclinical atherosclerosis. Three vaspin gene variants (rs2236242, rs7159023, and rs35262691) were genotyped by TaqMan probes. Serum vaspin levels were assessed by enzyme-linked immunosorbent assay. Statistical analysis was performed using STATA® v.11.1. Serum vaspin levels were significantly higher in female patients than in males and also in obese patients when compared to those with normal weight (p  Our results revealed that vaspin is linked to CV risk factors that may influence on the atherosclerotic process in axSpA. Additionally, we disclosed that serum vaspin concentration is genetically modulated in a large cohort of patients with axSpA.
PB BioMed Central
YR 2021
FD 2021-03-31
LK http://hdl.handle.net/10668/17571
UL http://hdl.handle.net/10668/17571
LA en
NO Rueda-Gotor J, López-Mejías R, Remuzgo-Martínez S, Pulito-Cueto V, Corrales A, Lera-Gómez L, et al. Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study. Arthritis Res Ther. 2021 Apr 13;23(1):111
DS RISalud
RD Apr 10, 2025