RT Journal Article
T1 Dietary Marine ω-3 Fatty Acids and Incident Sight-Threatening Retinopathy in Middle-Aged and Older Individuals With Type 2 Diabetes: Prospective Investigation From the PREDIMED Trial.
A1 Sala-Vila, Aleix
A1 Díaz-López, Andrés
A1 Valls-Pedret, Cinta
A1 Cofán, Montserrat
A1 García-Layana, Alfredo
A1 Lamuela-Raventós, Rosa-María
A1 Castañer, Olga
A1 Zanon-Moreno, Vicente
A1 Martinez-Gonzalez, Miguel A
A1 Toledo, Estefanía
A1 Basora, Josep
A1 Salas-Salvadó, Jordi
A1 Corella, Dolores
A1 Gómez-Gracia, Enrique
A1 Fiol, Miquel
A1 Estruch, Ramón
A1 Lapetra, José
A1 Fitó, Montserrat
A1 Arós, Fernando
A1 Serra-Majem, Luis
A1 Pintó, Xavier
A1 Ros, Emilio
A1 Prevención con Dieta Mediterránea (PREDIMED) Investigators, 
AB Diabetic retinopathy (DR) is a devastating complication of individuals with type 2 diabetes mellitus. The retina is rich in long-chain ω-3 polyunsaturated fatty acids (LCω3PUFAs), which are substrate for oxylipins with anti-inflammatory and antiangiogenic properties. Experimental models support dietary LCω3PUFA protection against DR, but clinical data are lacking. To determine whether LCω3PUFA intake relates to a decreased incidence of sight-threatening DR in individuals with type 2 diabetes older than 55 years. In late 2015, we conceived a prospective study within the randomized clinical trial Prevención con Dieta Mediterránea (PREDIMED), testing Mediterranean diets supplemented with extra virgin olive oil or nuts vs a control diet for primary cardiovascular prevention. The trial was conducted in primary health care centers in Spain. From 2003 to 2009, 3614 individuals aged 55 to 80 years with a previous diagnosis of type 2 diabetes were recruited. Full data were available for 3482 participants (48% men; mean age 67 years). Meeting the dietary LCω3PUFA recommendation of at least 500 mg/d for primary cardiovascular prevention, as assessed by a validated food-frequency questionnaire. The main outcome was incident DR requiring laser photocoagulation, vitrectomy, and/or antiangiogenic therapy confirmed by an external adjudication committee. Of the 3482 participants, 48% were men and the mean age was 67 years. A total of 2611 participants (75%) met target LCω3PUFA recommendation. During a median follow-up of 6 years, we documented 69 new events. After adjusting for age, sex, intervention group, and lifestyle and clinical variables, participants meeting the LCω3PUFA recommendation at baseline (≥500 mg/d) compared with those not fulfilling this recommendation ( In middle-aged and older individuals with type 2 diabetes, intake of at least 500 mg/d of dietary LCω3PUFA, easily achievable with 2 weekly servings of oily fish, is associated with a decreased risk of sight-threatening DR. Our results concur with findings from experimental models and the current model of DR pathogenesis. clinicaltrials.gov Identifier: http://www.controlled-trials.com/ISRCTN35739639.
YR 2016
FD 2016
LK http://hdl.handle.net/10668/10370
UL http://hdl.handle.net/10668/10370
LA en
DS RISalud
RD Apr 18, 2025