RT Generic
T1 Editorial: Involvements of TRP Channels, Oxidative Stress and Apoptosis in Neurodegenerative Diseases.
A1 Braidy, Nady
A1 Smani, Tarik
A1 Naziroglu, Mustafa
K1 TRP
K1 aging
K1 apoptosis
K1 neurodegeneration
K1 oxidative stress
AB The oxygen free radicals generated during metabolism can cause cumulative oxidative damage to nucleic acids , lipids , and protein , resulting in structural degeneration, apoptosis , functional decline, and age-related degenerative diseases involving the cardiovascular, endocrine, neurologic, immune, respiratory, gastrointestinal, and reproductive systems . The transient receptor potential (TRP) protein superfamily is composed of several cation -permeable channels that are widely distributed in mammalian cells . TRP channels can be divided into six subfamilies that are dependent on their sequence identity. These channels play a crucial role in the regulation of oxidative stress and should be considered as likely targets for the treatment of age-related neurodegenerative diseases associated with chronic oxidative stress , decreases in metabolic regulation , and cell viability .
PB Frontiers Research Foundation
SN 1664-042X
YR 2021
FD 2021-03-11
LK http://hdl.handle.net/10668/17417
UL http://hdl.handle.net/10668/17417
LA en
NO Braidy N, Smani T, Naziroglu M. Editorial: Involvements of TRP Channels, Oxidative Stress and Apoptosis in Neurodegenerative Diseases. Front Physiol. 2021 Mar 11;12:649230.
DS RISalud
RD Apr 7, 2025