RT Journal Article
T1 Partial Volume Correction Increases the Sensitivity of 18F-Florbetapir-Positron Emission Tomography for the Detection of Early Stage Amyloidosis
A1 Teipel, Stefan J.
A1 Dyrba, Martin
A1 Vergallo, Andrea
A1 Lista, Simone
A1 Habert, Marie Odile
A1 Potier, Marie-Claude
A1 Lamari, Foudil
A1 Dubois, Bruno
A1 Hampel, Harald
A1 Grothe, Michel J.
K1 amyloid PET
K1 cerebral amyloidosis
K1 partial volume effect
K1 cerebrospinal fluid
K1 Alzheimer's disease
K1 early detection
K1 Voxel-based analysis
K1 Cerebrospinal-fluid
K1 Quantitative-analysis
K1 White-matter
K1 Beta
K1 Brain
K1 Quantification
K1 Individuals
K1 Validation
K1 Deposition
AB Purpose: To test whether correcting for unspecific signal from the cerebral white matter increases the sensitivity of amyloid-PET for early stages of cerebral amyloidosis.Methods: We analyzed 18F-Florbetapir-PET and cerebrospinal fluid (CSF) A beta 42 data from 600 older individuals enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI), including people with normal cognition, mild cognitive impairment (MCI), and Alzheimer's disease (AD) dementia. We determined whether three compartmental partial volume correction (PVC-3), explicitly modeling signal spill-in from white matter, significantly improved the association of CSF A beta 42 levels with global 18F-Florbetapir-PET values compared with standard processing without PVC (non-PVC) and a widely used two-compartmental PVC method (PVC-2). In additional voxel-wise analyses, we determined the sensitivity of PVC-3 compared with non-PVC and PVC-2 for detecting early regional amyloid build-up as modeled by decreasing CSF A beta 42 levels. For replication, we included an independent sample of 43 older individuals with subjective memory complaints from the INveStIGation of AlzHeimer's PredicTors cohort (INSIGHT-preAD study).Results: In the ADNI sample, PVC-3 18F-Florbetapir-PET values normalized to whole cerebellum signal showed significantly stronger associations with CSF A beta 42 levels than non-PVC or PVC-2, particularly in the lower range of amyloid levels. These effects were replicated in the INSIGHT-preAD sample. PVC-3 18F-Florbetapir-PET data detected regional amyloid build-up already at higher (less abnormal) CSF A beta 42 levels than non-PVC or PVC-2 data.Conclusion: A PVC approach that explicitly models unspecific white matter binding improves the sensitivity of amyloid-PET for identifying the earliest stages of cerebral amyloid pathology which has implications for future primary prevention trials.
PB Frontiers media sa
SN 1663-4365
YR 2021
FD 2021-12-22
LK https://hdl.handle.net/10668/27833
UL https://hdl.handle.net/10668/27833
LA en
DS RISalud
RD Apr 8, 2025