RT Journal Article
T1 Optimizing the Limit of Detection of Waveguide-Based Interferometric Biosensor Devices
A1 Leuermann, Jonas
A1 Fernández-Gavela, Adrián
A1 Torres-Cubillo, Antonia
A1 Postigo, Sergio
A1 Sánchez-Postigo, Alejandro
A1 Lechuga, Laura M.
A1 Halir, Robert
A1 Molina-Fernández, Íñigo
K1 Biosensors
K1 Coherent detection
K1 Interferometer
K1 Limit of detection
K1 Silicon photonics
K1 Técnicas biosensibles
K1 Límite de detección
AB Waveguide-based photonic sensors provide a unique combination of high sensitivity, compact size and label-free, multiplexed operation. Interferometric configurations furthermore enable a simple, fixed-wavelength read-out making them particularly suitable for low-cost diagnostic and monitoring devices. Their limit of detection, i.e., the lowest analyte concentration that can be reliably observed, mainly depends on the sensors response to small refractive index changes, and the noise in the read-out system. While enhancements in the sensors response have been extensively studied, noise optimization has received much less attention. Here we show that order-of-magnitude enhancements in the limit of detection can be achieved through systematic noise reduction, and demonstrate a limit of detection of ∼ 10−8RIU with a silicon nitride sensor operating at telecom wavelengths.
PB MDPI
YR 2019
FD 2019-08-23
LK http://hdl.handle.net/10668/3341
UL http://hdl.handle.net/10668/3341
LA en
NO Leuermann J, Fernández-Gavela A, Torres-Cubillo A, Postigo S, Sánchez-Postigo A, Lechuga LM, et al. Optimizing the Limit of Detection of Waveguide-Based Interferometric Biosensor Devices. Sensors. 2019;19(17):3671.
DS RISalud
RD Apr 12, 2025