RT Journal Article
T1 Liver Enzymes Correlate With Metabolic Syndrome, Inflammation, and Endothelial Dysfunction in Prepubertal Children With Obesity.
A1 Valle-Martos, Rosario
A1 Valle, Miguel
A1 Martos, Rosario
A1 Cañete, Ramon
A1 Jimenez-Reina, Luis
A1 Cañete, Maria Dolores
K1 Endothel dysfunction
K1 Inflammation
K1 Liver enzymes
K1 Metabolic syndrome
K1 Obesity
K1 Prepuberal age
K1 AGS - Norte de Córdoba
AB Background: Metabolic syndrome (MetS) can start in children with obesity at very young ages. Non-alcoholic fatty liver disease (NAFLD) is considered to be the hepatic component of metabolic syndrome. If left untreated, the clinical course of NAFLD can be progressive and can become chronic if not detected at an early stage. Objective: We aimed to quantify the differences in liver enzymes between prepubertal children with obesity and children with normal weight to determine any associations between them and parameters related to MetS, adipokines, or markers of endothelial dysfunction and inflammation. Methods: This cross-sectional study included 54 prepuberal children with obesity (aged 6-9 years) and 54 children with normal weight, matched by age and sex. Liver enzymes, C-reactive protein (CRP), interleukin-6, soluble intercellular adhesion molecule-1 (sICAM-1), adipokines, and parameters related to metabolic syndrome (MetS) were all measured. Results: Alanine aminotransferase (ALT) levels, serum butyryl cholinesterase (BChE), leptin, CRP, sICAM-1, triglycerides, blood pressure, and homeostasis model assessment for insulin resistance were significantly higher in children with obesity, while Apolipoprotein A-1, HDL-cholesterol, and adiponectin were significantly lower. In the children with obesity group, ALT and BChE levels correlated with anthropometric measurements, insulin resistance, and lipid parameters, leptin, interleukin-6, CRP, and sICAM-1 while BChE levels negatively correlated with adiponectin. Conclusions: Compared to children with normal weight, prepubertal children with obesity had elevated values for liver enzymes, leptin, markers of insulin resistance, inflammation, and endothelial dysfunction, and variables associated with MetS. There was also a correlation between these disorders and liver enzyme levels.
PB Frontiers Research Foundation
SN 2296-2360
YR 2021
FD 2021-01-28
LK http://hdl.handle.net/10668/17274
UL http://hdl.handle.net/10668/17274
LA en
NO Valle-Martos R, Valle M, Martos R, Cañete R, Jiménez-Reina L, Cañete MD. Liver Enzymes Correlate With Metabolic Syndrome, Inflammation, and Endothelial Dysfunction in Prepubertal Children With Obesity. Front Pediatr. 2021 Feb 16;9:629346
NO This study was supported by grants from the Spanish Ministry of Health and the Fund for Research in Health [Fondo de Investigación Sanitaria (FIS PI021155)]
DS RISalud
RD Apr 8, 2025