RT Journal Article
T1 Matrix metalloproteases and TIMPs as prognostic biomarkers in breast cancer patients treated with radiotherapy: A pilot study.
A1 Olivares-Urbano, Maria Auxiliadora
A1 Griñan-Lison, Carmen
A1 Zurita, Mercedes
A1 Del Moral, Rosario
A1 Rios-Arrabal, Sandra
A1 Artacho-Cordon, Francisco
A1 Arrebola, Juan Pedro
A1 Gonzalez, Amanda Rocio
A1 Leon, Josefa
A1 Antonio Marchal, Juan
A1 Nuñez, Maria Isabel
K1 breast cancer patients
K1 matrix metalloproteases
K1 prognostic and predictive biomarkers
K1 radiotherapy
K1 tissue inhibitors
AB Breast cancer (BC) is the most common tumour in women and one of the most important causes of cancer death worldwide. Radiation therapy (RT) is widely used for BC treatment. Some proteins have been identified as prognostic factors for BC (Ki67, p53, E-cadherin, HER2). In the last years, it has been shown that variations in the expression of MMPs and TIMPs may contribute to the development of BC. The aim of this pilot work was to study the effects of RT on different MMPs (-1, -2, -3, -7, -8, -9, -10, -12 and -13) and TIMPs (-1 to -4), as well as their relationship with other variables related to patient characteristics and tumour biology. A group of 20 BC patients treated with RT were recruited. MMP and TIMP serum levels were analysed by immunoassay before, during and after RT. Our pilot study showed a slight increase in the levels of most MMP and TIMP with RT. However, RT produced a significantly decrease in TIMP-1 and TIMP-3 levels. Significant correlations were found between MMP-3 and TIMP-4 levels, and some of the variables studied related to patient characteristics and tumour biology. Moreover, MMP-9 and TIMP-3 levels could be predictive of RT toxicity. For this reason, MMP-3, MMP-9, TIMP-3 and TIMP-4 could be used as potential prognostic and predictive biomarkers for BC patients treated with RT.
PB Wiley-Blackwell Publishing Ltd.
YR 2019
FD 2019-08-01
LK http://hdl.handle.net/10668/14566
UL http://hdl.handle.net/10668/14566
LA en
DS RISalud
RD Apr 7, 2025